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Study · Animal study (in vivo) · rat · 1988

3 results

Differential responses of sex steroid target tissues of rats treated with 4-hydroxyandrostenedione.

Wing LY, Hammond JO, Brodie AM

Endocrinology1 Jun 1988Cited by 15 (Europe PMC)

PMID3131115 (opens in a new tab)DOI10.1210/endo-122-6-2418 (opens in a new tab)PepBankPUB-03131115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, enclomiphene did not block uterine growth stimulated by 4-OHA.

    In plain wordsIn rats, enclomiphene did not block uterine growth compared with 4-OHA alone.

    Peptide
    Enclomiphene
    Outcome
    No significant change4-OHA-stimulated uterine growth
    Study

    ratn: not reported in source

    Ovariectomized rats
    Comparator
    4-OHA alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulation of uterine growth by 4-OHA was also blocked by flutamide, but not by the antiestrogen enclomiphene.
    1 context sentence
    Summary · context
    The possible direct action of 4-OHA on gonadotropin secretion and uterine growth was, therefore, investigated in ovariectomized rats not treated with the carcinogen.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, enclomiphene did not counteract the reduction in uterine estrogen receptor levels induced by 4-OHA.

    In plain wordsIn rats, enclomiphene did not counteract lower uterine estrogen receptor levels compared with 4-OHA alone.

    Peptide
    Enclomiphene
    Outcome
    No significant changeUterine estrogen receptor levels
    Study

    ratn: not reported in source

    Ovariectomized rats
    Comparator
    4-OHA alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The reduction in uterine estrogen and progesterone receptor levels was also counteracted by the concomitant injection of flutamide, but not by enclomiphene.
    1 context sentence
    Summary · context
    The possible direct action of 4-OHA on gonadotropin secretion and uterine growth was, therefore, investigated in ovariectomized rats not treated with the carcinogen.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, enclomiphene did not counteract the reduction in uterine progesterone receptor levels induced by 4-OHA.

    In plain wordsIn rats, enclomiphene did not counteract lower uterine progesterone receptor levels compared with 4-OHA alone.

    Peptide
    Enclomiphene
    Outcome
    No significant changeUterine progesterone receptor levels
    Study

    ratn: not reported in source

    Ovariectomized rats
    Comparator
    4-OHA alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The reduction in uterine estrogen and progesterone receptor levels was also counteracted by the concomitant injection of flutamide, but not by enclomiphene.
    1 context sentence
    Summary · context
    The possible direct action of 4-OHA on gonadotropin secretion and uterine growth was, therefore, investigated in ovariectomized rats not treated with the carcinogen.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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