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Study · Measured the body's own peptide · 1987

3 results

Analysis of peptide histidine-isoleucine/vasoactive intestinal polypeptide-immunoreactive neurons in the central nervous system with special reference to their relation to corticotropin releasing factor- and enkephalin-like immunoreactivities in the paraventricular hypothalamic nucleus.

Hökfelt T, Fahrenkrug J, Ju G, Ceccatelli S, Tsuruo Y, Meister B, Mutt V, Rundgren M, Brodin E, Terenius L

Neuroscience1 Dec 1987Cited by 70 (Europe PMC)

PMID3125490 (opens in a new tab)DOI10.1016/0306-4522(87)90162-x (opens in a new tab)PepBankPUB-03125490
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In the rat central nervous system, PHI-like and VIP-like immunoreactivity had parallel and overlapping distribution in all areas investigated.

    In plain wordsIn rats, the body's own VIP and a related peptide were found in the same places in the brain and spinal cord.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableDistribution of VIP-like and PHI-like immunoreactivity
    Study

    ratn: not reported in source

    Rat central nervous system
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    (2) PHI- and VIP-like immunoreactivity were found with parallel and overlapping distribution in all areas investigated in the rat central nervous system.
    1 context sentence
    Summary · context
    The distribution of peptide histidine-isoleucine (PHI) and vasoactive intestinal polypeptide (VIP), two peptides derived from the same precursor molecule, was analysed with immunohistochemistry in the central nervous system of the rat, and to a limited extent in some other species including sheep, monkey and man.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In the rat central nervous system, coexistence of PHI-like and VIP-like immunoreactivity could be directly demonstrated in many cases.

    In plain wordsIn rats, the body's own VIP and a related peptide were often found in the same nerve cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableCoexistence of PHI and VIP immunoreactivity
    Study

    ratn: not reported in source

    Rat central nervous system
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    In many cases coexistence of the two immunoreactivities could be directly demonstrated.
    1 context sentence
    Summary · context
    The distribution of peptide histidine-isoleucine (PHI) and vasoactive intestinal polypeptide (VIP), two peptides derived from the same precursor molecule, was analysed with immunohistochemistry in the central nervous system of the rat, and to a limited extent in some other species including sheep, monkey and man.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In the rat paraventricular nucleus, some cells contained VIP-like as well as PHI-like immunoreactivity, shown with antisera that did not cross-react with corticotropin releasing factor.

    In plain wordsIn rats, some cells in a hypothalamic area contained both the body's own VIP and a related peptide.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP and PHI immunoreactivity in paraventricular nucleus cells
    Study

    ratn: not reported in source

    Rat central nervous system
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    some cells did, in fact, contain VIP- as well as PHI-like immunoreactivity as was shown with antisera not cross-reacting with corticotropin releasing factor.
    1 context sentence
    Summary · context
    The distribution of peptide histidine-isoleucine (PHI) and vasoactive intestinal polypeptide (VIP), two peptides derived from the same precursor molecule, was analysed with immunohistochemistry in the central nervous system of the rat, and to a limited extent in some other species including sheep, monkey and man.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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