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Study · Non-randomized trial · n = 14 · 1987

13 results

The effect of rectal and nasal administration of salmon calcitonin in normal subjects.

Buclin T, Randin JP, Jacquet AF, Azria M, Attinger M, Gomez F, Burckhardt P

Calcified tissue international1 Nov 1987Cited by 51 (Europe PMC)

PMID3121149 (opens in a new tab)DOI10.1007/bf02555225 (opens in a new tab)PepBankPUB-03121149
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. 13 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In normal subjects, plasma sodium did not increase after rectal salmon calcitonin, whereas it increased in untreated controls.

    In plain wordsIn normal subjects, blood sodium did not increase after rectal salmon calcitonin, whereas it increased in untreated controls.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changePlasma sodium after rectal dosing
    Study

    n = 14

    Comparator
    Untreated controls
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Plasma sodium did not increase, whereas it did in the controls.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  2. 02HumanNon-randomized trialActivity measurement

    In normal subjects, plasma sodium did not increase after nasal salmon calcitonin, whereas it increased in untreated controls.

    In plain wordsIn normal subjects, blood sodium did not increase after nasal salmon calcitonin, whereas it increased in untreated controls.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changePlasma sodium after nasal dosing
    Study

    n = 13

    Comparator
    Untreated controls
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Plasma sodium did not increase, whereas it did in the controls.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  3. 03HumanNon-randomized trialPharmacokinetics

    In normal subjects, rectal salmon calcitonin sharply increased plasma concentrations, with higher and shorter peaks than nasal dosing.

    In plain wordsIn normal subjects, rectal salmon calcitonin increased blood levels, with higher and shorter peaks than nasal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePlasma salmon calcitonin after rectal dosing
    Study

    n = 9

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Plasma concentrations of SCT were found to increase sharply with both routes of administration, the peaks being high and short after rectal administration, low but more sustained after nasal application.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  4. 04HumanNon-randomized trialActivity measurement

    In normal subjects, rectal salmon calcitonin produced transient hypocalcemia, with effects almost similar to nasal dosing.

    In plain wordsIn normal subjects, rectal salmon calcitonin temporarily lowered blood calcium, with effects almost similar to nasal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseTransient hypocalcemia after rectal dosing
    Study

    n = 9

    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  5. 05HumanNon-randomized trialActivity measurement

    In normal subjects, rectal salmon calcitonin increased calciuria, with effects almost similar to nasal dosing.

    In plain wordsIn normal subjects, rectal salmon calcitonin increased urinary calcium, with effects almost similar to nasal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseCalciuria after rectal dosing
    Study

    n = 9

    Comparator
    Previous-day values
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  6. 06HumanNon-randomized trialActivity measurement

    In normal subjects, rectal salmon calcitonin increased phosphaturia, with effects almost similar to nasal dosing.

    In plain wordsIn normal subjects, rectal salmon calcitonin increased urinary phosphate, with effects almost similar to nasal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePhosphaturia after rectal dosing
    Study

    n = 9

    Comparator
    Previous-day values
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  7. 07HumanNon-randomized trialActivity measurement

    In normal subjects, rectal salmon calcitonin increased natriuria, with effects almost similar to nasal dosing.

    In plain wordsIn normal subjects, rectal salmon calcitonin increased urinary sodium, with effects almost similar to nasal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseNatriuria after rectal dosing
    Study

    n = 9

    Comparator
    Previous-day values
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Two doses of 200 IU at 3 hour intervals · rectalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  8. 08HumanNon-randomized trialPharmacokinetics

    In normal subjects, nasal salmon calcitonin sharply increased plasma concentrations, with lower but more sustained peaks than rectal dosing.

    In plain wordsIn normal subjects, nasal salmon calcitonin increased blood levels, with lower but longer peaks than rectal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePlasma salmon calcitonin after nasal dosing
    Study

    n = 8

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Plasma concentrations of SCT were found to increase sharply with both routes of administration, the peaks being high and short after rectal administration, low but more sustained after nasal application.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  9. 09HumanNon-randomized trialActivity measurement

    In normal subjects, nasal salmon calcitonin produced transient hypocalcemia, with effects almost similar to rectal dosing.

    In plain wordsIn normal subjects, nasal salmon calcitonin temporarily lowered blood calcium, with effects almost similar to rectal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseTransient hypocalcemia after nasal dosing
    Study

    n = 8

    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    2 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
  10. 10HumanNon-randomized trialActivity measurement

    In normal subjects, nasal salmon calcitonin increased calciuria, with effects almost similar to rectal dosing.

    In plain wordsIn normal subjects, nasal salmon calcitonin increased urinary calcium, with effects almost similar to rectal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseCalciuria after nasal dosing
    Study

    n = 8

    Comparator
    Previous-day values
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  11. 11HumanNon-randomized trialActivity measurement

    In normal subjects, nasal salmon calcitonin increased phosphaturia, with effects almost similar to rectal dosing.

    In plain wordsIn normal subjects, nasal salmon calcitonin increased urinary phosphate, with effects almost similar to rectal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasePhosphaturia after nasal dosing
    Study

    n = 8

    Comparator
    Previous-day values
    Outcome group
    Electrolyte balance · Endocrine and hormones
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  12. 12HumanNon-randomized trialActivity measurement

    In normal subjects, nasal salmon calcitonin increased natriuria, with effects almost similar to rectal dosing.

    In plain wordsIn normal subjects, nasal salmon calcitonin increased urinary sodium, with effects almost similar to rectal dosing.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseNatriuria after nasal dosing
    Study

    n = 8

    Comparator
    Previous-day values
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Despite these differences, almost similar biologic effects could be demonstrated: transient hypocalcemia, increased calciuria, phosphaturia, and natriuria.
    3 context sentences
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
  13. 13HumanNon-randomized trialActivity measurement

    In normal subjects receiving nasal salmon calcitonin, urinary hydroxyproline excretion decreased.

    In plain wordsIn normal subjects receiving nasal salmon calcitonin, urinary hydroxyproline decreased.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseUrinary hydroxyproline excretion
    Study

    n = 8

    Comparator
    Previous-day values
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Two doses of 200 IU at 3 hour intervals · nasalAs given in this study (human).

    Source sentences

    Summary
    Urinary hydroxyproline excretion decreased.
    3 context sentences
    Summary · context
    Modifications in fractionated urinary calcium, phosphate, sodium, and creatinine excretions (and hydroxyproline for the 8 subjects treated by the nasal spray) were compared with the values measured on the previous day.
    Summary · context
    In order to ascertain the blood levels and the biologic responses obtained after administration of two noninjectable forms of salmon calcitonin (SCT) (i.e., a nasal spray and a suppository), two doses of 200 IU each were administered at 3 hour intervals nasally to 8 normal subjects, and rectally to 9 normal subjects.
    Summary · context
    Five untreated subjects served as controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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