Skip to content

Study · Non-randomized trial · n = 20 · 1987

4 results

Oxytocin enhances thyrotropin-releasing hormone-induced prolactin release in normal menstruating women.

Coiro V, Gnudi A, Volpi R, Marchesi C, Salati G, Caffarra P, Chiodera P

Fertility and sterility1 Apr 1987Cited by 7 (Europe PMC)

PMID3106095 (opens in a new tab)DOI10.1016/s0015-0282(16)59103-1 (opens in a new tab)PepBankPUB-03106095
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal menstruating women, oxytocin did not change TRH-stimulated TSH secretion compared with TRH alone.

    In plain wordsIn healthy women, oxytocin did not change the thyroid-stimulating hormone response to TRH compared with TRH alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeTRH-stimulated TSH secretion
    Study

    n = 20

    Comparator
    TRH alone
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    on the TRH-stimulated TSH secretion
    2 context sentences
    Summary · context
    The effects of oxytocin (OT) on basal thyrotropin-releasing hormone (TRH)-stimulated thyrotropin (TSH) and prolactin (PRL) secretion were evaluated in normal menstruating women during follicular, periovulatory, and luteal phases.
    Summary · context
    In one study, 15 subjects were treated with OT or saline; in the other study, 20 women were tested with TRH alone or in combination with OT.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal menstruating women, oxytocin significantly enhanced the prolactin response to TRH compared with TRH alone; the peak was about three times basal with TRH alone and about four times with oxytocin.

    In plain wordsIn healthy women, oxytocin enhanced the prolactin response to TRH compared with TRH alone, in all phases of the menstrual cycle.

    Peptide
    Oxytocin
    Outcome
    IncreaseTRH-induced prolactin response
    Study

    n = 20

    Comparator
    TRH alone
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas it significantly enhanced the PRL response to TRH.
    3 context sentences
    Summary · context
    At all examined phases during the menstrual cycle, the mean peak PRL response was reached within 20 minutes after TRH injection, and the peak was about three times higher than basal value when TRH was given alone and about four times when OT was present.
    Summary · context
    The effects of oxytocin (OT) on basal thyrotropin-releasing hormone (TRH)-stimulated thyrotropin (TSH) and prolactin (PRL) secretion were evaluated in normal menstruating women during follicular, periovulatory, and luteal phases.
    Summary · context
    In one study, 15 subjects were treated with OT or saline; in the other study, 20 women were tested with TRH alone or in combination with OT.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal menstruating women, oxytocin did not change basal serum TSH levels.

    In plain wordsIn healthy women, oxytocin did not change basal thyroid-stimulating hormone levels compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal serum TSH
    Study

    n = 15

    Comparator
    Saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT did not produce any effect on basal serum TSH and PRL levels
    2 context sentences
    Summary · context
    The effects of oxytocin (OT) on basal thyrotropin-releasing hormone (TRH)-stimulated thyrotropin (TSH) and prolactin (PRL) secretion were evaluated in normal menstruating women during follicular, periovulatory, and luteal phases.
    Summary · context
    In one study, 15 subjects were treated with OT or saline; in the other study, 20 women were tested with TRH alone or in combination with OT.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normal menstruating women, oxytocin did not change basal serum prolactin levels.

    In plain wordsIn healthy women, oxytocin did not change basal prolactin levels compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal serum prolactin
    Study

    n = 15

    Comparator
    Saline
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT did not produce any effect on basal serum TSH and PRL levels
    2 context sentences
    Summary · context
    The effects of oxytocin (OT) on basal thyrotropin-releasing hormone (TRH)-stimulated thyrotropin (TSH) and prolactin (PRL) secretion were evaluated in normal menstruating women during follicular, periovulatory, and luteal phases.
    Summary · context
    In one study, 15 subjects were treated with OT or saline; in the other study, 20 women were tested with TRH alone or in combination with OT.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.