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Study · Non-randomized trial · n = 4 · 1986

9 results

Positive nitrogen balance with human growth hormone and hypocaloric intravenous feeding.

Manson JM, Wilmore DW

Surgery1 Aug 1986Cited by 123 (Europe PMC)

PMID3090723 (opens in a new tab)PepBankPUB-03090723
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH decreased weight loss compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH reduced weight loss compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseWeight loss
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Administration of GH decreased weight loss, caused retention of nitrogen, potassium, and phosphorus in amounts closely matching their proportions in skeletal muscle, and stimulated insulin production.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  2. 02HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH caused nitrogen retention compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH increased nitrogen retention compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseNitrogen retention
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Administration of GH decreased weight loss, caused retention of nitrogen, potassium, and phosphorus in amounts closely matching their proportions in skeletal muscle, and stimulated insulin production.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  3. 03HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH caused potassium retention compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH increased potassium retention compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreasePotassium retention
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Electrolytes · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Administration of GH decreased weight loss, caused retention of nitrogen, potassium, and phosphorus in amounts closely matching their proportions in skeletal muscle, and stimulated insulin production.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  4. 04HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH caused phosphorus retention compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH increased phosphorus retention compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreasePhosphorus retention
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Electrolytes · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Administration of GH decreased weight loss, caused retention of nitrogen, potassium, and phosphorus in amounts closely matching their proportions in skeletal muscle, and stimulated insulin production.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  5. 05HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH stimulated insulin production compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH increased insulin production compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseInsulin production
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Administration of GH decreased weight loss, caused retention of nitrogen, potassium, and phosphorus in amounts closely matching their proportions in skeletal muscle, and stimulated insulin production.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  6. 06HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH raised serum free fatty acids compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH raised free fatty acids compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum free fatty acids
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    GH also raised serum levels of free fatty acids and glycerol, increased urinary excretion of ketones, and favored fat oxidation in the postabsorptive state.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  7. 07HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH raised serum glycerol compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH raised glycerol compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum glycerol
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    GH also raised serum levels of free fatty acids and glycerol, increased urinary excretion of ketones, and favored fat oxidation in the postabsorptive state.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  8. 08HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH increased urinary ketone excretion compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH increased urinary ketones compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseUrinary ketone excretion
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    GH also raised serum levels of free fatty acids and glycerol, increased urinary excretion of ketones, and favored fat oxidation in the postabsorptive state.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.
  9. 09HumanNon-randomized trialEfficacy outcome

    In men receiving hypocaloric nutrition, GH favored postabsorptive fat oxidation compared with the placebo period.

    In plain wordsIn men receiving reduced-calorie nutrition, GH favored fat oxidation compared with the placebo period.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreasePostabsorptive fat oxidation
    Study

    n = 4

    Comparator
    Placebo period
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    10 mg daily · 7 daysAs given in this study (human).

    Source sentences

    Summary
    GH also raised serum levels of free fatty acids and glycerol, increased urinary excretion of ketones, and favored fat oxidation in the postabsorptive state.
    3 context sentences
    Summary · context
    To investigate the hormonal environment under which nitrogen retention might be achieved during hypocaloric feedings, we administered peripheral vein nutrition with growth hormone (GH) to four healthy male patients.
    Summary · context
    The intravenous diets provided 50% of estimated energy requirements (mean 566 kcal/m2/day) and adequate nitrogen (6 gm/m2/day).
    Summary · context
    Each subject was studied for two 7-day periods; 10 mg of GH was given daily during one period and placebo during the other.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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