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Study · In vitro (cells) · mouse · 1986

6 results

The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo.

Schmidt GE, Kim MH, Mansour R, Torello L, Friedman CI

American journal of obstetrics and gynecology1 Apr 1986Cited by 26 (Europe PMC)

PMID3083679 (opens in a new tab)DOI10.1016/0002-9378(86)90444-8 (opens in a new tab)PepBankPUB-03083679
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Safety outcome

    In cultured mouse oocytes, enclomiphene adversely affected fertilization rates in a dose-dependent manner.

    In plain wordsIn lab tests with mouse oocytes, enclomiphene reduced fertilization rates as concentrations increased.

    Peptide
    Enclomiphene
    Outcome
    DecreaseFertilization rate
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    1 context sentence
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.
  2. 02LabIn vitro (cells)Safety outcome

    In cultured mouse embryos, enclomiphene adversely affected blastocyst formation rates in a dose-dependent manner.

    In plain wordsIn lab tests with mouse embryos, enclomiphene reduced blastocyst formation rates as concentrations increased.

    Peptide
    Enclomiphene
    Outcome
    DecreaseBlastocyst formation rate
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    1 context sentence
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.
  3. 03LabIn vitro (cells)Safety outcome

    In cultured mouse embryos, enclomiphene adversely affected degeneration rates in a dose-dependent manner.

    In plain wordsIn lab tests with mouse embryos, enclomiphene increased degeneration rates as concentrations increased.

    Peptide
    Enclomiphene
    Outcome
    IncreaseDegeneration rate
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    1 context sentence
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.
  4. 04LabIn vitro (cells)Safety outcome

    In cultured mouse oocytes, fertilization rates did not differ significantly between enclomiphene and zuclomiphene.

    In plain wordsIn lab tests with mouse oocytes, fertilization rates did not differ significantly between enclomiphene and zuclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeFertilization rate versus zuclomiphene
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Comparator
    Zuclomiphene
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no statistically significant differences between the two isomers.
    2 context sentences
    Summary · context
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.
  5. 05LabIn vitro (cells)Safety outcome

    In cultured mouse embryos, blastocyst formation rates did not differ significantly between enclomiphene and zuclomiphene.

    In plain wordsIn lab tests with mouse embryos, blastocyst formation rates did not differ significantly between enclomiphene and zuclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeBlastocyst formation rate versus zuclomiphene
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Comparator
    Zuclomiphene
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no statistically significant differences between the two isomers.
    2 context sentences
    Summary · context
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.
  6. 06LabIn vitro (cells)Safety outcome

    In cultured mouse embryos, degeneration rates did not differ significantly between enclomiphene and zuclomiphene.

    In plain wordsIn lab tests with mouse embryos, degeneration rates did not differ significantly between enclomiphene and zuclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeDegeneration rate versus zuclomiphene
    Study

    mousen: not reported in source

    Mouse oocytes and embryos in culture
    Comparator
    Zuclomiphene
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no statistically significant differences between the two isomers.
    2 context sentences
    Summary · context
    Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion.
    Summary · context
    To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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