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Study · Randomized controlled trial · n = 6 · 1986

10 results

Single-dose pharmacokinetics of leuprolide in humans following intravenous and subcutaneous administration.

Sennello LT, Finley RA, Chu SY, Jagst C, Max D, Rollins DE, Tolman KG

Journal of pharmaceutical sciences1 Feb 1986Cited by 34 (Europe PMC)

PMID3083092 (opens in a new tab)DOI10.1002/jps.2600750211 (opens in a new tab)PepBankPUB-03083092
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide half-life was 2.9 h intravenously and 3.6 h subcutaneously, without a significant route difference.

    In plain wordsIn male volunteers, leuprolide half-life did not differ significantly between intravenous and subcutaneous administration.

    Peptide
    Leuprolide
    Outcome
    No significant changeElimination half-life
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Measurements

    Half-life
    2.9 h
    intravenous
    Half-life
    3.6 h
    subcutaneous

    Source sentences

    Summary
    The mean beta half-life after the intravenous dosings was 2.9 h and after the subcutaneous dosings was 3.6 h.
    3 context sentences
    Summary · context
    The difference between these two values, as well as those for plasma clearance, variance in residence time, and volume of distribution at steady state was not statistically significant;
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  2. 02HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide plasma clearance did not differ significantly between intravenous and subcutaneous dosing.

    In plain wordsIn male volunteers, leuprolide clearance did not differ significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    No significant changePlasma clearance
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The difference between these two values, as well as those for plasma clearance, variance in residence time, and volume of distribution at steady state was not statistically significant;
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  3. 03HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide residence-time variance did not differ significantly between routes.

    In plain wordsIn male volunteers, residence-time variance did not differ significantly between intravenous and subcutaneous leuprolide.

    Peptide
    Leuprolide
    Outcome
    No significant changeVariance in residence time
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The difference between these two values, as well as those for plasma clearance, variance in residence time, and volume of distribution at steady state was not statistically significant;
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  4. 04HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide steady-state distribution volumes were 26.5 L intravenously and 37.1 L subcutaneously, without a significant difference.

    In plain wordsIn male volunteers, leuprolide distribution volume did not differ significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    No significant changeSteady-state distribution volume
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Measurements

    Volume
    26.5 L
    intravenous
    Volume
    37.1 L
    subcutaneous

    Source sentences

    Summary
    The mean volume of distribution at steady state from the intravenous and subcutaneous doses were 26.5 and 37.1 L, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
    3 context sentences
    Summary · context
    The difference between these two values, as well as those for plasma clearance, variance in residence time, and volume of distribution at steady state was not statistically significant;
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  5. 05HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide k21 differed significantly between intravenous and subcutaneous dosing.

    In plain wordsIn male volunteers, leuprolide k21 differed significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedk21
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  6. 06HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide k12 differed significantly between intravenous and subcutaneous dosing.

    In plain wordsIn male volunteers, leuprolide k12 differed significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedk12
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  7. 07HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide kel differed significantly between intravenous and subcutaneous dosing.

    In plain wordsIn male volunteers, leuprolide kel differed significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedkel
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  8. 08HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide central compartment apparent distribution volume differed significantly between routes.

    In plain wordsIn male volunteers, leuprolide central compartment distribution volume differed significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedCentral compartment apparent distribution volume
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  9. 09HumanRandomized controlled trialPharmacokinetics

    In male volunteers, mean leuprolide residence time was significantly longer subcutaneously than intravenously, at 4.3 versus 3.1 h.

    In plain wordsIn male volunteers, leuprolide remained longer after subcutaneous dosing than after intravenous dosing.

    Peptide
    Leuprolide
    Outcome
    IncreaseMean residence time
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Measurements

    Residence time
    4.3 h
    subcutaneous
    Residence time
    3.1 h
    intravenous
    Injection-site residence time
    1.2 h
    subcutaneous

    Source sentences

    Summary
    The mean residence time following the intravenous dosings averaged 3.1 h and following the subcutaneous dosings averaged 4.3 h, indicating an average mean residence time at the subcutaneous injection site of 1.2 h.
    3 context sentences
    Summary · context
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.
  10. 10HumanRandomized controlled trialPharmacokinetics

    In male volunteers, leuprolide area under the moment curve differed significantly between routes.

    In plain wordsIn male volunteers, leuprolide area under the moment curve differed significantly between intravenous and subcutaneous dosing.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedArea under the moment curve
    Study

    n = 6

    Comparator
    Subcutaneous versus intravenous leuprolide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 mg · intravenous and subcutaneousAs given in this study (human).

    Source sentences

    Summary
    however, the differences between the mean values of k21, k12, kel, apparent volume of distribution of the central compartment, mean residence time, and area under the moment curve for the routes of administration were significant (p less than 0.05).
    2 context sentences
    Summary · context
    A group of six normal adult male volunteers was divided into two groups (I and II) who received bolus intravenous and subcutaneous 1-mg doses of leuprolide.
    Summary · context
    The study was of a randomized, complete-crossover design.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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