Thymosin alpha‑1 fragment 13-19 increased 5'NT activity in cord blood lymphocytes, with activity approximately equal to that of thymosin alpha‑1.
In plain wordsIn cells, one piece of thymosin alpha‑1 raised an enzyme activity in newborn blood cells about as much as the whole peptide.
- Peptide
- Thymosin alpha-1
- Outcome
- Increase5'NT activity with fragment 13-19
- Study
humann: not reported in source
Cord blood T lymphocytes- Comparator
- Parent peptide thymosin alpha 1
- Outcome group
- Immune response · Immune and inflammation
Source sentences
In the range of 1.3 X 10 to 1.3 X 10(-5)M, one of the eleven peptides examined (sequence 13-19) exhibited activity approximately equal to that of the parent peptide thymosin alpha 1: increase in activity of 5'NT (p less than 0.01) and reduction of cells positive for OKT4 (p less than 0.01).
2 context sentences(design, population, supporting numbers)
In this study, the effects of these synthetic peptide fragments on cord blood T lymphocytes were studied.
After incubation with different peptide sequences, cord blood lymphocytes were analysed for surface antigenic markers (OKT4/OKT8) and for purine degradative enzymes (PNP, 5 NT).
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.