In perifused rat adrenal cells, thymosin alpha‑1 synergistically stimulated corticotropin-stimulated corticosterone release.
In plain wordsIn rat adrenal cells in the lab, thymosin alpha‑1 increased corticosterone release that corticotropin had already stimulated.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseCorticotropin-stimulated corticosterone release
- Study
ratn: not reported in source
rat adrenal cells in an in vitro perifusion system- Comparator
- Corticotropin alone
- Outcome group
- Stress hormones · Endocrine and hormones
- Studied dose
- Dose not stated
Source sentences
thymosin alpha 1, a 28-amino acid residue peptide found both in thymus and lymphocyte-derived supernatants was also able to synergistically stimulate corticotropin-stimulated corticosterone release
1 context sentence(design, population, supporting numbers)
We now provide evidence that heterogeneous lymphokine-containing supernatants from mitogen-stimulated rat spleen cells can stimulate both basal and corticotropin-induced corticosterone secretion from rat adrenal cells in an in vitro perifusion system.