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Study · Non-randomized trial · 1986

5 results

Role of oxytocin in the modulation of ACTH release in women.

Suh BY, Liu JH, Rasmussen DD, Gibbs DM, Steinberg J, Yen SS

Neuroendocrinology1 Jan 1986Cited by 20 (Europe PMC)

PMID3027599 (opens in a new tab)DOI10.1159/000124661 (opens in a new tab)PepBankPUB-03027599
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In women, intravenous oxytocin did not significantly change basal ACTH-cortisol release.

    In plain wordsIn women, oxytocin did not change the body's baseline ACTH and cortisol release.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal ACTH-cortisol release
    Study

    n: not reported in source

    Comparator
    Saline
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 IU intravenous bolus followed by 111 mIU/min infusion · intravenous · 3 hAs given in this study (human).

    Source sentences

    Summary
    OT administration (2 IU intravenous bolus followed by 111 mIU/min infusion for 3 h) maintained a circulating concentration of 7.7 X 10(-8) M and did not significantly influence basal, AVP or CRF-induced ACTH-cortisol release.
    1 context sentence
    Summary · context
    To determine if oxytocin (OT) may have a modulatory role on corticotropin-releasing factor (CRF) and vasopressin (AVP) mediated ACTH-cortisol release in women, serial experiments were performed in which saline, OT, AVP and CRF were administered singly or in combinations.
  2. 02HumanNon-randomized trialEfficacy outcome

    In women, oxytocin did not significantly change vasopressin-induced ACTH-cortisol release.

    In plain wordsIn women, oxytocin did not change the ACTH and cortisol release that vasopressin caused.

    Peptide
    Oxytocin
    Outcome
    No significant changeAVP-induced ACTH-cortisol release
    Study

    n: not reported in source

    Comparator
    Vasopressin alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 IU intravenous bolus followed by 111 mIU/min infusion · intravenous · 3 hAs given in this study (human).

    Source sentences

    Summary
    OT administration (2 IU intravenous bolus followed by 111 mIU/min infusion for 3 h) maintained a circulating concentration of 7.7 X 10(-8) M and did not significantly influence basal, AVP or CRF-induced ACTH-cortisol release.
    1 context sentence
    Summary · context
    To determine if oxytocin (OT) may have a modulatory role on corticotropin-releasing factor (CRF) and vasopressin (AVP) mediated ACTH-cortisol release in women, serial experiments were performed in which saline, OT, AVP and CRF were administered singly or in combinations.
  3. 03HumanNon-randomized trialEfficacy outcome

    In women, oxytocin did not significantly change CRF-induced ACTH-cortisol release.

    In plain wordsIn women, oxytocin did not change the ACTH and cortisol release that CRF caused.

    Peptide
    Oxytocin
    Outcome
    No significant changeCRF-induced ACTH-cortisol release
    Study

    n: not reported in source

    Comparator
    CRF alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 IU intravenous bolus followed by 111 mIU/min infusion · intravenous · 3 hAs given in this study (human).

    Source sentences

    Summary
    OT administration (2 IU intravenous bolus followed by 111 mIU/min infusion for 3 h) maintained a circulating concentration of 7.7 X 10(-8) M and did not significantly influence basal, AVP or CRF-induced ACTH-cortisol release.
    1 context sentence
    Summary · context
    To determine if oxytocin (OT) may have a modulatory role on corticotropin-releasing factor (CRF) and vasopressin (AVP) mediated ACTH-cortisol release in women, serial experiments were performed in which saline, OT, AVP and CRF were administered singly or in combinations.
  4. 04HumanNon-randomized trialEfficacy outcome

    In women, oxytocin significantly inhibited the potentiating effect of vasopressin on CRF-stimulated ACTH-cortisol release.

    In plain wordsIn women, oxytocin reduced the boost that vasopressin gives to CRF-driven ACTH and cortisol release.

    Peptide
    Oxytocin
    Outcome
    DecreaseAVP potentiation of CRF-stimulated ACTH-cortisol release
    Study

    n: not reported in source

    Comparator
    CRF plus AVP without oxytocin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 IU intravenous bolus followed by 111 mIU/min infusion · intravenous · 3 hAs given in this study (human).

    Source sentences

    Summary
    In contrast, OT inhibited significantly the potentiating effect of AVP on CRF-stimulated ACTH-cortisol release.
    1 context sentence
    Summary · context
    To determine if oxytocin (OT) may have a modulatory role on corticotropin-releasing factor (CRF) and vasopressin (AVP) mediated ACTH-cortisol release in women, serial experiments were performed in which saline, OT, AVP and CRF were administered singly or in combinations.
  5. 05HumanNon-randomized trialPharmacokinetics

    In women, the bolus and 3 h infusion of oxytocin maintained a circulating oxytocin concentration of 7.7 X 10(-8) M.

    In plain wordsIn women, the oxytocin bolus and infusion held a steady oxytocin level in the blood.

    Peptide
    Oxytocin
    Outcome
    Not applicableCirculating oxytocin concentration during infusion
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 IU intravenous bolus followed by 111 mIU/min infusion · intravenous · 3 hAs given in this study (human).

    Source sentences

    Summary
    maintained a circulating concentration of 7.7 X 10(-8) M
    1 context sentence
    Summary · context
    To determine if oxytocin (OT) may have a modulatory role on corticotropin-releasing factor (CRF) and vasopressin (AVP) mediated ACTH-cortisol release in women, serial experiments were performed in which saline, OT, AVP and CRF were administered singly or in combinations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT01039766

The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)

Sheba Medical Centern = 24Feb 2010 to est. Jun 2011

Stress Disorders, Post-Traumatic

Trial pageClinicalTrials.govUpdated 9 Feb 2010

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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