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Study · Ex vivo tissue · pig · 1987

4 results

Identification and characterization of two classes of receptors for oxytocin and vasopressin in porcine tunica albuginea, epididymis, and vas deferens.

Maggi M, Malozowski S, Kassis S, Guardabasso V, Rodbard D

Endocrinology1 Mar 1987Cited by 63 (Europe PMC)

PMID3026794 (opens in a new tab)DOI10.1210/endo-120-3-986 (opens in a new tab)PepBankPUB-03026794
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In porcine tunica albuginea, epididymis and vas deferens membranes, oxytocin bound with high affinity to a class of sites designated the OT site.

    In plain wordsIn pig tissue membranes in the lab, oxytocin bound strongly to a specific oxytocin receptor site.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin binding site affinity
    Study

    pign: not reported in source

    membranes from tunica albuginea, epididymis and vas deferens of prepubertal pigs
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The first class of sites, designated the OT site, shows high affinity for OT
    1 context sentence
    Summary · context
    We investigated the presence of specific binding sites for [3H]OT and [3H]arginine VP (AVP) in membranes prepared from tunica albuginea, epididymis, and vas deferens from prepubertal pigs 2-16 weeks of age.
  2. 02LabEx vivo tissueActivity measurement

    In porcine male genital tract membranes, the highest density of oxytocin receptors was found in tunica albuginea and epididymis.

    In plain wordsIn pig tissue membranes in the lab, oxytocin receptors were most dense in tunica albuginea and epididymis.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor density by tissue
    Study

    pign: not reported in source

    membranes from tunica albuginea, epididymis and vas deferens of prepubertal pigs
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The highest density of OT receptors was found in tunica albuginea and epididymis
    1 context sentence
    Summary · context
    We investigated the presence of specific binding sites for [3H]OT and [3H]arginine VP (AVP) in membranes prepared from tunica albuginea, epididymis, and vas deferens from prepubertal pigs 2-16 weeks of age.
  3. 03LabEx vivo tissueMechanism

    In porcine male genital tract membranes, millimolar Mg2+ increased the specific binding of oxytocin and vasopressin ligands.

    In plain wordsIn pig tissue membranes in the lab, magnesium increased how much oxytocin bound to its receptor sites.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffect of Mg2+ on [3H]OT specific binding
    Study

    pign: not reported in source

    membranes from tunica albuginea, epididymis and vas deferens of prepubertal pigs
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Millimolar concentrations of Mg2+ increased the specific binding of both ligands.
    1 context sentence
    Summary · context
    We investigated the presence of specific binding sites for [3H]OT and [3H]arginine VP (AVP) in membranes prepared from tunica albuginea, epididymis, and vas deferens from prepubertal pigs 2-16 weeks of age.
  4. 04LabEx vivo tissueMechanism

    In porcine tunica albuginea, epididymis and vas deferens, oxytocin at concentrations up to 100-fold greater than its Kd did not activate adenylate cyclase.

    In plain wordsIn pig tissue in the lab, oxytocin did not switch on the adenylate cyclase enzyme, even at high concentrations.

    Peptide
    Oxytocin
    Outcome
    No significant changeAdenylate cyclase activation by oxytocin
    Study

    pign: not reported in source

    membranes from tunica albuginea, epididymis and vas deferens of prepubertal pigs
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    up to 100-fold greater than KdAs given in this study (pig).

    Source sentences

    Summary
    Adenylate cyclase was not activated in any of the tissues studied by concentrations of AVP or OT up to 100-fold greater than their Kd values.
    1 context sentence
    Summary · context
    We investigated the presence of specific binding sites for [3H]OT and [3H]arginine VP (AVP) in membranes prepared from tunica albuginea, epididymis, and vas deferens from prepubertal pigs 2-16 weeks of age.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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