In Brattleboro rats, chronic oxytocin reduced pituitary vasopressin receptor concentration by 20-30%, compared with about 80% for the same dose of vasopressin.
In plain wordsIn Brattleboro rats, long-term oxytocin lowered pituitary vasopressin receptors much less than the same dose of vasopressin did.
- Peptide
- Oxytocin
- Outcome
- DecreasePituitary AVP receptor concentration after chronic oxytocin
- Study
ratn: not reported in source
Brattleboro homozygous rats (lack AVP)- Comparator
- Vasopressin (same dose)
- Outcome group
- Receptor activity and mechanism · Endocrine and hormones
- Studied dose
- Dose not stated · chronicAs given in this study (rat).
Measurements
- Receptor concentration reduction
- 20 to 30%
- Brattleboro homozygous rats, oxytocin
Source sentences
In HO, chronic administration of VP reduced receptor concentration by about 80%, while the same dose of oxytocin (OT) produced only a 20-30% reduction.
1 context sentence(design, population, supporting numbers)
The regulation of pituitary vasopressin (VP) receptor concentration was investigated in rats with antero-lateral cuts (ALC) placed around the hypothalamus, as well as in Brattleboro homozygotes (HO) that genetically suffer from a lack of AVP.