Skip to content

Study · Ex vivo tissue · rat · 1986

6 results

Delta-sleep-inducing peptide (DSIP) inhibited CRF-induced ACTH secretion from rat anterior pituitary gland in vitro.

Okajima T, Hertting G

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Jul 1986Cited by 11 (Europe PMC)

PMID3017833 (opens in a new tab)DOI10.1055/s-2007-1012357 (opens in a new tab)PepBankPUB-03017833
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In rat anterior pituitary tissue in vitro, DSIP significantly inhibited CRF-induced ACTH release.

    In plain wordsIn lab tests on rat pituitary tissue, DSIP reduced the ACTH release triggered by CRF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCRF-induced ACTH release
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10(-9) - 10(-7) MAs given in this study (rat).

    Source sentences

    Summary
    Delta-sleep-inducing peptide (DSIP, 10(-9) - 10(-7) M) significantly inhibited the CRF-induced ACTH release from rat anterior pituitary quarters in vitro.
  2. 02LabEx vivo tissueMechanism

    In rat anterior pituitary tissue in vitro, 10(-8) M DSIP showed the most prominent inhibition of CRF-induced ACTH release.

    In plain wordsIn lab tests on rat pituitary tissue, one middle DSIP concentration gave the strongest block of CRF-induced ACTH release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMost effective DSIP concentration for ACTH inhibition
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10(-8) MAs given in this study (rat).

    Source sentences

    Summary
    10(-8) M DSIP showed the most prominent inhibition.
  3. 03LabEx vivo tissueMechanism

    In rat anterior pituitary tissue in vitro, DSIP inhibited CRF-activated cAMP levels.

    In plain wordsIn lab tests on rat pituitary tissue, DSIP lowered the cAMP rise triggered by CRF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCRF-activated cAMP levels
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10(-8) MAs given in this study (rat).

    Source sentences

    Summary
    DSIP (10(-8) M) also inhibited the CRF-activated cAMP levels in anterior pituitary tissue.
  4. 04LabEx vivo tissueMechanism

    In rat anterior pituitary tissue in vitro, DSIP did not influence basal ACTH levels.

    In plain wordsIn lab tests on rat pituitary tissue, DSIP did not change baseline ACTH release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal ACTH release
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP did not influence basal ACTH or cAMP levels.
  5. 05LabEx vivo tissueMechanism

    In rat anterior pituitary tissue in vitro, DSIP did not influence basal cAMP levels.

    In plain wordsIn lab tests on rat pituitary tissue, DSIP did not change baseline cAMP levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBasal cAMP levels
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP did not influence basal ACTH or cAMP levels.
  6. 06LabEx vivo tissueMechanism

    In rat anterior pituitary tissue in vitro, DSIP did not change PGE2 release.

    In plain wordsIn lab tests on rat pituitary tissue, DSIP did not change prostaglandin E2 release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeProstaglandin E2 (PGE2) release
    Study

    ratn: not reported in source

    anterior pituitary quarters
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Prostaglandin E2 (PGE2)-release from anterior pituitary quarters was not changed by DSIP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.