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Study · Animal study (in vivo) · rat · 1986

6 results

A comparison of grooming behavior potencies of neurohypophyseal nonapeptides.

Caldwell JD, Drago F, Prange AJ Jr, Pedersen CA

Regulatory peptides1 May 1986Cited by 24 (Europe PMC)

PMID3014615 (opens in a new tab)DOI10.1016/0167-0115(86)90009-1 (opens in a new tab)PepBankPUB-03014615
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, intracerebroventricular oxytocin at 1 microgram increased grooming behavior; vasopressin, vasotocin, lysine-vasopressin and alpha-MSH were as effective.

    In plain wordsIn female rats, oxytocin injected into the brain increased grooming, and several related peptides were just as effective.

    Peptide
    Oxytocin
    Outcome
    IncreaseGrooming behavior at 1 microgram
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    1 microgram · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    At this dose arginine-vasopressin (AVP), arginine-vasotocin (AVT) and lysine-vasopressin (LVP), as well as alpha-MSH, were as effective as OXY in increasing grooming behavior.
    1 context sentence
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, grooming scores increased in an apparent linear manner across the oxytocin dose range.

    In plain wordsIn female rats, grooming scores rose roughly in step with the oxytocin dose.

    Peptide
    Oxytocin
    Outcome
    IncreaseGrooming score across the oxytocin dose range
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    range similar to 0.05-5 micrograms · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Grooming scores increased in an apparent linear manner across a similar OXY dose range.
    2 context sentences
    Summary · context
    The potency of AVP and AVT was determined across a 0.05-5 microgram dose range.
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, oxytocin elevated body grooming.

    In plain wordsIn female rats, oxytocin increased body grooming.

    Peptide
    Oxytocin
    Outcome
    IncreaseBody grooming
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Analyses of the aspects of grooming separately found that nonapeptides OXY, AVP and AVT all elevated body grooming, washing, and scratching.
    1 context sentence
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, oxytocin elevated washing.

    In plain wordsIn female rats, oxytocin increased washing behavior.

    Peptide
    Oxytocin
    Outcome
    IncreaseWashing
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Analyses of the aspects of grooming separately found that nonapeptides OXY, AVP and AVT all elevated body grooming, washing, and scratching.
    1 context sentence
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, oxytocin elevated scratching.

    In plain wordsIn female rats, oxytocin increased scratching.

    Peptide
    Oxytocin
    Outcome
    IncreaseScratching
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Analyses of the aspects of grooming separately found that nonapeptides OXY, AVP and AVT all elevated body grooming, washing, and scratching.
    1 context sentence
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, oxytocin produced significantly lower grooming scores than arginine-vasotocin and arginine-vasopressin at lower doses.

    In plain wordsIn female rats, oxytocin produced lower grooming scores than vasotocin and vasopressin at lower doses.

    Peptide
    Oxytocin
    Outcome
    DecreaseGrooming score versus AVT and AVP at lower doses
    Study

    ratn: not reported in source

    Female rats
    Comparator
    Arginine-vasotocin and arginine-vasopressin
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Because AVT and AVP administration resulted in grooming scores significantly higher than OXY at lower doses
    1 context sentence
    Summary · context
    In the present study female rats were injected ICV with 1 microgram OXY or equimolar doses of other peptides.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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