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Study · Animal study (in vivo) · rabbit · 1986

5 results

Autonomic effects of centrally administered dermorphin in conscious rabbits.

Tartara A, Maurelli M, Marchioni E

Il Farmaco; edizione scientifica1 Mar 1986Cited by 1 (Europe PMC)

PMID3011495 (opens in a new tab)PepBankPUB-03011495
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rabbits, dermorphin significantly decreased heart rate.

    In plain wordsIn rabbits, dermorphin lowered heart rate.

    Peptide
    Dermorphin
    Outcome
    DecreaseHeart rate
    Study

    rabbitn: not reported in source

    conscious rabbits
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 microgram · mesencephalic ventricleAs given in this study (rabbit).

    Source sentences

    Summary
    The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rabbits, dermorphin significantly decreased respiratory rate.

    In plain wordsIn rabbits, dermorphin lowered breathing rate.

    Peptide
    Dermorphin
    Outcome
    DecreaseRespiratory rate
    Study

    rabbitn: not reported in source

    conscious rabbits
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    1 microgram · mesencephalic ventricleAs given in this study (rabbit).

    Source sentences

    Summary
    The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rabbits, dermorphin significantly decreased body temperature.

    In plain wordsIn rabbits, dermorphin lowered body temperature.

    Peptide
    Dermorphin
    Outcome
    DecreaseBody temperature
    Study

    rabbitn: not reported in source

    conscious rabbits
    Outcome group
    Body temperature · Whole body
    Studied dose
    1 microgram · mesencephalic ventricleAs given in this study (rabbit).

    Source sentences

    Summary
    The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In conscious rabbits, naloxone completely reversed dermorphin-induced decreases in heart rate, respiratory rate and temperature.

    In plain wordsIn rabbits, naloxone completely reversed dermorphin-induced decreases in heart rate, breathing rate and temperature.

    Peptide
    Dermorphin
    Outcome
    Not applicableNaloxone reversal of autonomic effects
    Study

    rabbitn: not reported in source

    conscious rabbits
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    1 microgram · mesencephalic ventricleAs given in this study (rabbit).

    Source sentences

    Summary
    Naloxone completely reverses such effects.
    1 context sentence
    Summary · context
    The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In conscious rabbits, pretreatment with serotoninergic, catecholaminergic, Gabaergic and cholinergic system inhibitors did not affect central dermorphin actions.

    In plain wordsIn rabbits, pretreatment with inhibitors of the listed neurotransmitter systems did not affect dermorphin-induced autonomic changes.

    Peptide
    Dermorphin
    Outcome
    No significant changeAutonomic effects after neurotransmitter system inhibition
    Study

    rabbitn: not reported in source

    conscious rabbits
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    1 microgram · mesencephalic ventricleAs given in this study (rabbit).

    Source sentences

    Summary
    Pretreatment with drugs which inhibit serotoninergic, catecholaminergic, Gabaergic and cholinergic systems does not affect these central dermorphin actions.
    1 context sentence
    Summary · context
    The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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