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Study · Not a test of the peptide alone · 1986

3 results

Neutralization of HTLV-III/LAV replication by antiserum to thymosin alpha 1.

Sarin PS, Sun DK, Thornton AH, Naylor PH, Goldstein AL

Science (New York, N.Y.)1 May 1986Cited by 95 (Europe PMC)

PMID3010464 (opens in a new tab)DOI10.1126/science.3010464 (opens in a new tab)PepBankPUB-03010464
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In H9 cells, an antiserum raised against thymosin alpha‑1 neutralized the AIDS-associated virus HTLV-III/LAV and blocked its replication.

    In plain wordsIn cells, an antibody serum made against thymosin alpha‑1 stopped the AIDS virus from copying itself. Thymosin alpha‑1 itself was not given.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHTLV-III/LAV replication in H9 cells
    Study

    n: not reported in source

    H9 cells
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    An antiserum prepared against thymosin alpha 1, a hormone secreted by the thymus gland, effectively neutralized the AIDS-associated virus [HTLV-III/LAV (clone BH-10)] and blocked its replication in H9 cells.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In cells infected with HTLV-III/LAV, purified IgG from antisera to thymosin alpha‑1 inhibited reverse transcriptase activity and expression of the antigens p15 and p24.

    In plain wordsIn lab tests, antibodies against thymosin alpha‑1 reduced virus enzyme activity and virus protein production. Thymosin alpha‑1 itself was not given.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseReverse transcriptase activity and p15/p24 antigen expression
    Study

    n: not reported in source

    H9 cells
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    Reverse transcriptase activity and expression of the HTLV-III/LAV antigens p15 and p24 were inhibited by purified immunoglobulin G preparations of antisera to thymosin alpha 1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03Computer modelNot a test of Thymosin alpha-1 aloneIn silicoOther

    A sequence comparison found 44% to 50% homology between an 18-amino acid region of thymosin alpha‑1 and the gag protein of HTLV-III/LAV.

    In plain wordsA computer comparison found that part of thymosin alpha‑1 looks 44 to 50 percent like a virus protein.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableSequence homology between thymosin alpha 1 and HTLV-III/LAV gag protein
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Infection

    Measurements

    sequence homology
    44 to 50%
    18-amino acid region, thymosin alpha 1 positions 11-28 vs gag positions 92-109

    Source sentences

    Summary
    Comparison of the primary sequences of thymosin alpha 1 and the gag protein revealed a 44% to 50% homology in an 18-amino acid region, between positions 11 and 28 on thymosin alpha 1 and 92 and 109 on the gag protein.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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