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Study · Animal study (in vivo) · rat · 1986

2 results

Corticotropin inhibits food intake in rats.

Vergoni AV, Poggioli R, Bertolini A

Neuropeptides1 Feb 1986Cited by 58 (Europe PMC)

PMID3010169 (opens in a new tab)DOI10.1016/0143-4179(86)90091-0 (opens in a new tab)PepBankPUB-03010169
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In starved rats, ventricular tetracosactide reduced food intake by 76.6% during the first hour, with maximal effectiveness at 4 micrograms/rat.

    In plain wordsIn starved rats, tetracosactide injected into a brain ventricle reduced food intake during the first hour.

    Peptide
    Cosyntropin
    Outcome
    DecreaseFood intake after ventricular injection
    Study

    ratsn: not reported in source

    Rats starved for 24h
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    4 micrograms/rat · Brain lateral ventricle injection · First hour after treatmentAs given in this study (rats).

    Measurements

    Food intake reduction
    76.6%
    first hour

    Source sentences

    Summary
    In starved rats, the dose of 4 micrograms/rat was maximally effective and reduced food intake by 76.6% during the first hour after treatment.
    1 context sentence
    Summary · context
    The synthetic corticotropin ACTH (1-24) (tetracosactide), injected into a brain lateral ventricle after a 24h starvation period or into the ventromedial hypothalamus during the nocturnal feeding phase, markedly inhibited food intake, in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In normally fed rats, hypothalamic tetracosactide reduced nocturnal food intake by 58.6% during 90 minutes.

    In plain wordsIn normally fed rats, tetracosactide injected into the hypothalamus reduced nocturnal food intake.

    Peptide
    Cosyntropin
    Outcome
    DecreaseFood intake after hypothalamic injection
    Study

    ratsn: not reported in source

    Normally fed rats during nocturnal feeding
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    4 micrograms/rat · Ventromedial hypothalamus injection · 90 minutesAs given in this study (rats).

    Measurements

    Food intake reduction
    58.6%
    90 minutes

    Source sentences

    Summary
    The same dose, injected into the ventromedial hypothalamus, significantly inhibited food intake also in normally fed rats during the nocturnal phase (58.6% reduction during the 90 minutes of observation).
    1 context sentence
    Summary · context
    In starved rats, the dose of 4 micrograms/rat was maximally effective and reduced food intake by 76.6% during the first hour after treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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