Stress-specific modulation of ACTH secretion by oxytocin.

Gibbs DM

Neuroendocrinology1 Jan 1986Cited by 47 (Europe PMC)

PMID3010155DOI10.1159/000124487PepBankPUB-03010155

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In untreated rats, the body's own oxytocin levels rose in response to tail-hang and ether stress.
In plain wordsIn rats, the body's own oxytocin levels rose after tail-hang and ether stress.
Peptide
Oxytocin
Outcome
IncreaseOxytocin level rise after tail-hang and ether stress
Study
ratn: not reported in source
Rats under three stresses (novel environment, tail-hang, ether)
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
whereas OT levels increased only in response to tail-hang and ether.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to one of three stresses: novel environment, tail-hang, or ether.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0301015501
02AnimalEndogenous levelAnimal study (in vivo)Other
In untreated rats, the body's own oxytocin levels did not rise in response to novel environment stress.
In plain wordsIn rats, the body's own oxytocin levels did not rise after novel environment stress.
Peptide
Oxytocin
Outcome
No significant changeOxytocin level after novel environment stress
Study
ratn: not reported in source
Rats under three stresses (novel environment, tail-hang, ether)
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
whereas OT levels increased only in response to tail-hang and ether.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were subjected to one of three stresses: novel environment, tail-hang, or ether.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0301015502

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, an antiserum that neutralised oxytocin inhibited the ACTH response to tail-hang and ether stress by 64 and 56%, respectively.
In plain wordsIn rats, blocking the body's own oxytocin with an antiserum cut the ACTH stress response to tail-hang and ether.
Peptide
Oxytocin
Outcome
DecreaseACTH response to tail-hang and ether after OT antiserum
Study
ratn: not reported in source
Rats under three stresses (novel environment, tail-hang, ether)
Outcome group
Stress hormones · Endocrine and hormones
Measurements
ACTH response inhibition
64%
tail-hang
ACTH response inhibition
56%
ether
Source sentences
Summary
Injection of a highly specific antiserum to OT 60 min before the experiment inhibited the ACTH response to tail-hang and ether by 64 and 56%, respectively, but had no effect on the ACTH response to novel environment stress.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of oxytocin (OT) in regulating stress-induced ACTH secretion was investigated by immunoneutralization of endogenous OT with an antiserum raised against synthetic OT.
Summary · context
Rats were subjected to one of three stresses: novel environment, tail-hang, or ether.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0301015503
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, an antiserum that neutralised oxytocin had no effect on the ACTH response to novel environment stress.
In plain wordsIn rats, blocking the body's own oxytocin with an antiserum did not change the ACTH response to a novel environment.
Peptide
Oxytocin
Outcome
No significant changeACTH response to novel environment after OT antiserum
Study
ratn: not reported in source
Rats under three stresses (novel environment, tail-hang, ether)
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
Injection of a highly specific antiserum to OT 60 min before the experiment inhibited the ACTH response to tail-hang and ether by 64 and 56%, respectively, but had no effect on the ACTH response to novel environment stress.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of oxytocin (OT) in regulating stress-induced ACTH secretion was investigated by immunoneutralization of endogenous OT with an antiserum raised against synthetic OT.
Summary · context
Rats were subjected to one of three stresses: novel environment, tail-hang, or ether.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0301015504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

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