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Study · Animal study (in vivo) · bulls · 1986

14 results

Elevation of serum testosterone during chronic LHRH agonist treatment in the bull.

Melson BE, Brown JL, Schoenemann HM, Tarnavsky GK, Reeves JJ

Journal of animal science1 Jan 1986Cited by 22 (Europe PMC)

PMID3007418 (opens in a new tab)DOI10.2527/jas1986.621199x (opens in a new tab)PepBankPUB-03007418
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin initially raised serum LH, which returned to basal concentrations by 12 h.

    In plain wordsIn bulls, nafarelin initially raised LH, which returned to baseline by 12 h.

    Peptide
    Nafarelin
    Outcome
    MixedInitial LH response
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and T were elevated after initial injection of LHRH-A, but returned to basal concentrations by 12, 5 and 17 h, respectively.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin initially raised serum FSH, which returned to basal concentrations by 5 h.

    In plain wordsIn bulls, nafarelin initially raised FSH, which returned to baseline by 5 h.

    Peptide
    Nafarelin
    Outcome
    MixedInitial FSH response
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and T were elevated after initial injection of LHRH-A, but returned to basal concentrations by 12, 5 and 17 h, respectively.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin initially raised testosterone, which returned to basal concentrations by 17 h.

    In plain wordsIn bulls, nafarelin initially raised testosterone, which returned to baseline by 17 h.

    Peptide
    Nafarelin
    Outcome
    MixedInitial testosterone response
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and T were elevated after initial injection of LHRH-A, but returned to basal concentrations by 12, 5 and 17 h, respectively.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In bulls, prolonged nafarelin prevented pulsatile LH secretion compared with controls.

    In plain wordsIn bulls, prolonged nafarelin prevented pulsatile LH secretion compared with controls.

    Peptide
    Nafarelin
    Outcome
    DecreasePulsatile LH secretion
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Prolonged LHRH-A treatment prevented pulsatile LH and T secretion compared with control bulls.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In bulls, prolonged nafarelin prevented pulsatile testosterone secretion compared with controls.

    In plain wordsIn bulls, prolonged nafarelin prevented pulsatile testosterone secretion compared with controls.

    Peptide
    Nafarelin
    Outcome
    DecreasePulsatile testosterone secretion
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Prolonged LHRH-A treatment prevented pulsatile LH and T secretion compared with control bulls.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In bulls, mean LH did not differ from controls on days 4, 8 and 14 of nafarelin treatment.

    In plain wordsIn bulls, mean LH did not differ from controls on days 4, 8 and 14 of nafarelin treatment.

    Peptide
    Nafarelin
    Outcome
    No significant changeMean serum LH
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Mean serum LH did not differ from that of controls on d 4, 8 and 14 of LHRH-A treatment, while serum T was elevated (P less than .01) during the same time periods.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  7. 07AnimalAnimal study (in vivo)Activity measurement

    In bulls, testosterone was higher than controls on days 4, 8 and 14 of nafarelin treatment.

    In plain wordsIn bulls, testosterone was higher than controls on days 4, 8 and 14 of nafarelin treatment.

    Peptide
    Nafarelin
    Outcome
    IncreaseMean testosterone
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Mean serum LH did not differ from that of controls on d 4, 8 and 14 of LHRH-A treatment, while serum T was elevated (P less than .01) during the same time periods.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  8. 08AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin did not alter FSH oscillating patterns compared with controls.

    In plain wordsIn bulls, nafarelin did not alter FSH oscillating patterns compared with controls.

    Peptide
    Nafarelin
    Outcome
    No significant changeFSH oscillating patterns
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Oscillating patterns and mean concentrations of serum FSH were not different between control and LHRH-A-treated bulls.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  9. 09AnimalAnimal study (in vivo)Activity measurement

    In bulls, mean FSH did not differ between nafarelin and control groups.

    In plain wordsIn bulls, mean FSH did not differ between nafarelin and control groups.

    Peptide
    Nafarelin
    Outcome
    No significant changeMean FSH
    Study

    bullsn: not reported in source

    sexually mature bulls
    Comparator
    control bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscularAs given in this study (bulls).

    Source sentences

    Summary
    Oscillating patterns and mean concentrations of serum FSH were not different between control and LHRH-A-treated bulls.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  10. 10AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin reduced pituitary LHRH receptor numbers.

    In plain wordsIn bulls, nafarelin reduced pituitary LHRH receptor numbers.

    Peptide
    Nafarelin
    Outcome
    DecreasePituitary LHRH receptors
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Fifteen days of LHRH-A treatment depressed pituitary LHRH receptor numbers (P less than .05) and pituitary LH (P less than .01) and FSH (P less than .05) concentrations.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  11. 11AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin reduced pituitary LH concentrations.

    In plain wordsIn bulls, nafarelin reduced pituitary LH concentrations.

    Peptide
    Nafarelin
    Outcome
    DecreasePituitary LH
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Fifteen days of LHRH-A treatment depressed pituitary LHRH receptor numbers (P less than .05) and pituitary LH (P less than .01) and FSH (P less than .05) concentrations.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  12. 12AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin reduced pituitary FSH concentrations.

    In plain wordsIn bulls, nafarelin reduced pituitary FSH concentrations.

    Peptide
    Nafarelin
    Outcome
    DecreasePituitary FSH
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Fifteen days of LHRH-A treatment depressed pituitary LHRH receptor numbers (P less than .05) and pituitary LH (P less than .01) and FSH (P less than .05) concentrations.
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  13. 13AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin increased testicular LH receptor numbers.

    In plain wordsIn bulls, nafarelin increased testicular LH receptor numbers.

    Peptide
    Nafarelin
    Outcome
    IncreaseTesticular LH receptors
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Testicular LH receptor numbers were elevated (P less than .01), but testicular FSH receptor numbers were not altered.(ABSTRACT TRUNCATED AT 250 WORDS)
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.
  14. 14AnimalAnimal study (in vivo)Activity measurement

    In bulls, nafarelin did not alter testicular FSH receptor numbers.

    In plain wordsIn bulls, nafarelin did not alter testicular FSH receptor numbers.

    Peptide
    Nafarelin
    Outcome
    No significant changeTesticular FSH receptors
    Study

    bullsn: not reported in source

    sexually mature bulls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    150 micrograms every 6 h · intramuscular · 15 dAs given in this study (bulls).

    Source sentences

    Summary
    Testicular LH receptor numbers were elevated (P less than .01), but testicular FSH receptor numbers were not altered.(ABSTRACT TRUNCATED AT 250 WORDS)
    3 context sentences
    Summary · context
    Eight sexually mature bulls (325 to 475 kg) were assigned to treatment or control groups.
    Summary · context
    Treatment consisted of 150 micrograms nafarelin acetate 6-D-2-naphthyl-alanine-LHRH (LHRH-A) injected im every 6 h for 15 d.
    Summary · context
    Bovine serum albumin (BSA, .01%) in a carrier solution was injected at the same times in control bulls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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