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Study · Non-randomized trial · n = 6 · 1985

3 results

Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, beta-endorphin, and beta-lipotropin in man.

Degli Uberti EC, Petraglia F, Trasforini G, Salvadori S, Margutti A, Bianconi M, Teodori V, Facchinetti F, Tomatis R, Genazzani AR

The Journal of clinical endocrinology and metabolism1 Dec 1985Cited by 3 (Europe PMC)

PMID2997256 (opens in a new tab)DOI10.1210/jcem-61-6-1018 (opens in a new tab)PepBankPUB-02997256
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin suppressed metyrapone-evoked ACTH release compared with saline infusion.

    In plain wordsIn men, dermorphin reduced metyrapone-evoked ACTH release compared with saline infusion.

    Peptide
    Dermorphin
    Outcome
    DecreaseMetyrapone-evoked ACTH release
    Study

    n = 6

    Comparator
    saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion.
    1 context sentence
    Summary · context
    Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin suppressed metyrapone-evoked beta-lipotropin release compared with saline infusion.

    In plain wordsIn men, dermorphin reduced metyrapone-evoked beta-lipotropin release compared with saline infusion.

    Peptide
    Dermorphin
    Outcome
    DecreaseMetyrapone-evoked beta-lipotropin release
    Study

    n = 6

    Comparator
    saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion.
    1 context sentence
    Summary · context
    Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal men, dermorphin suppressed metyrapone-evoked beta-endorphin release compared with saline infusion.

    In plain wordsIn men, dermorphin reduced metyrapone-evoked beta-endorphin release compared with saline infusion.

    Peptide
    Dermorphin
    Outcome
    DecreaseMetyrapone-evoked beta-endorphin release
    Study

    n = 6

    Comparator
    saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5.5 micrograms/kg X min · infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion.
    1 context sentence
    Summary · context
    Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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