Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.

Kovács GL, Horváth Z, Sarnyai Z, Faludi M, Telegdy G

Neuropharmacology1 May 1985Cited by 64 (Europe PMC)

PMID2991800DOI10.1016/0028-3908(85)90026-7PepBankPUB-02991800

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin attenuated the development of acute tolerance to the antinociceptive effect of morphine.
In plain wordsIn mice, oxytocin reduced the build-up of acute tolerance to the pain-relieving effect of morphine.
Peptide
Oxytocin
Outcome
DecreaseAcute tolerance to morphine antinociception
Study
mousen: not reported in source
Morphine tolerance and dependence
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and the dipeptides attenuated the development of acute and chronic tolerance to the antinociceptive effect of morphine and delayed the onset of the naloxone-precipitated withdrawal syndrome.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Report a problemFND-0299180001
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin attenuated the development of chronic tolerance to the antinociceptive effect of morphine.
In plain wordsIn mice, oxytocin reduced the build-up of chronic tolerance to the pain-relieving effect of morphine.
Peptide
Oxytocin
Outcome
DecreaseChronic tolerance to morphine antinociception
Study
mousen: not reported in source
Morphine tolerance and dependence
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and the dipeptides attenuated the development of acute and chronic tolerance to the antinociceptive effect of morphine and delayed the onset of the naloxone-precipitated withdrawal syndrome.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Report a problemFND-0299180002
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, oxytocin delayed the onset of the naloxone-precipitated morphine withdrawal syndrome.
In plain wordsIn mice, oxytocin delayed the start of withdrawal signs after naloxone in morphine-treated animals.
Peptide
Oxytocin
Outcome
IncreaseOnset latency of naloxone-precipitated withdrawal syndrome
Study
mousen: not reported in source
Morphine tolerance and dependence
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and the dipeptides attenuated the development of acute and chronic tolerance to the antinociceptive effect of morphine and delayed the onset of the naloxone-precipitated withdrawal syndrome.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Report a problemFND-0299180003
04AnimalAnimal study (in vivo)Mechanism
In mice, oxytocin potentiated the hypermotility induced by a large dose of apomorphine.
In plain wordsIn mice, oxytocin increased the extra movement caused by a large dose of apomorphine.
Peptide
Oxytocin
Outcome
IncreaseApomorphine-induced hypermotility
Study
mousen: not reported in source
Drug-induced behavioural responses related to dopamine in the brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Thus, oxytocin potentiated the hypermotility induced by a large dose of apomorphine and decreased the supersensitivity of the DA receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Report a problemFND-0299180004
05AnimalAnimal study (in vivo)Mechanism
In mice, oxytocin decreased the supersensitivity of dopamine receptors.
In plain wordsIn mice, oxytocin reduced the over-sensitivity of dopamine receptors.
Peptide
Oxytocin
Outcome
DecreaseDopamine receptor supersensitivity
Study
mousen: not reported in source
Drug-induced behavioural responses related to dopamine in the brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Thus, oxytocin potentiated the hypermotility induced by a large dose of apomorphine and decreased the supersensitivity of the DA receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse.
Report a problemFND-0299180005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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