Terminal differentiation of cord blood lymphocytes induced by thymosin fraction 5 and thymosin alpha 1.

Ho AD, Stehle B, Dietz G, Hunstein W, Hoffbrand AV

Scandinavian journal of immunology1 Mar 1985Cited by 9 (Europe PMC)

PMID2986276DOI10.1111/j.1365-3083.1985.tb01424.xPepBankPUB-02986276

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In human cord blood lymphocytes, 40 h incubation with thymosin alpha‑1 raised ecto-5'-nucleotidase levels to a pattern like adult lymphocytes.
In plain wordsIn lab tests on human cord blood lymphocytes, thymosin alpha‑1 raised 5'-nucleotidase levels to a pattern like adult cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseEcto-5'-nucleotidase activity in cord blood lymphocytes
Study
humann: not reported in source
cord blood lymphocytes
Outcome group
Immune response · Immune and inflammation
Studied dose
1 microgram/ml · 40 hAs given in this study (human).
Source sentences
Summary
Incubation of CBL with TMS-F5 (150 micrograms/ml) and TMS-alpha 1 (1 microgram/ml) for 40 h caused a significant rise in 5'NT level
2 context sentences(design, population, supporting numbers)
Summary · context
Thus TMS-F5 might induce the terminal differentiation of CBL, and TMS-alpha 1 seemed to be the active component.
Summary · context
We have investigated the effects of TMS-F5 and TMS-alpha 1 on the pattern of the purine degradative enzymes adenosine deaminase, purine nucleoside phosphorylase, and ecto-5'-nucleotidase (5'NT) of CBL and on the phenotypic markers from the OKT series 3, 4, 8 and 11.
Report a problemFND-0298627601
02LabEx vivo tissueActivity measurement
In human cord blood lymphocytes, 40 h incubation with thymosin alpha‑1 decreased the percentage of OKT4-positive cells to a pattern like adult lymphocytes.
In plain wordsIn lab tests on human cord blood lymphocytes, thymosin alpha‑1 lowered the share of OKT4-positive cells to a pattern like adult cells.
Peptide
Thymosin alpha-1
Outcome
DecreaseOKT4-positive cell percentage in cord blood lymphocytes
Study
humann: not reported in source
cord blood lymphocytes
Outcome group
Immune response · Immune and inflammation
Studied dose
1 microgram/ml · 40 hAs given in this study (human).
Source sentences
Summary
Incubation of CBL with TMS-F5 (150 micrograms/ml) and TMS-alpha 1 (1 microgram/ml) for 40 h
3 context sentences(design, population, supporting numbers)
Summary · context
decrease of cells positive for OKT4, resulting in a pattern characteristic of NAL.
Summary · context
Thus TMS-F5 might induce the terminal differentiation of CBL, and TMS-alpha 1 seemed to be the active component.
Summary · context
We have investigated the effects of TMS-F5 and TMS-alpha 1 on the pattern of the purine degradative enzymes adenosine deaminase, purine nucleoside phosphorylase, and ecto-5'-nucleotidase (5'NT) of CBL and on the phenotypic markers from the OKT series 3, 4, 8 and 11.
Report a problemFND-0298627602

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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