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Study · Non-randomized trial · 1985

10 results

Oxytocin does not influence adrenocorticotropin secretion in man.

Lewis DA, Sherman BM

The Journal of clinical endocrinology and metabolism1 Jan 1985Cited by 19 (Europe PMC)

PMID2981086 (opens in a new tab)DOI10.1210/jcem-60-1-53 (opens in a new tab)PepBankPUB-02981086
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal men, iv bolus oxytocin at four doses did not change morning plasma ACTH compared with placebo.

    In plain wordsIn healthy men, oxytocin given by injection did not change morning ACTH levels compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMorning plasma ACTH after oxytocin bolus
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    30, 60, 90 and 120 mU/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Using four different doses of oxytocin (30, 60, 90, and 120 mU/kg), given by iv bolus injection, we found no difference in the effect of oxytocin on morning ACTH and cortisol levels compared with the effect of a placebo.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal men, iv bolus oxytocin at four doses did not change morning plasma cortisol compared with placebo.

    In plain wordsIn healthy men, oxytocin given by injection did not change morning cortisol levels compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMorning plasma cortisol after oxytocin bolus
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    30, 60, 90 and 120 mU/kg · iv bolusAs given in this study (human).

    Source sentences

    Summary
    Using four different doses of oxytocin (30, 60, 90, and 120 mU/kg), given by iv bolus injection, we found no difference in the effect of oxytocin on morning ACTH and cortisol levels compared with the effect of a placebo.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not suppress basal plasma ACTH.

    In plain wordsIn healthy men, a long oxytocin infusion did not lower basal ACTH levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal ACTH during prolonged oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not suppress basal plasma cortisol.

    In plain wordsIn healthy men, a long oxytocin infusion did not lower basal cortisol levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal cortisol during prolonged oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  5. 05HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not delay the normal circadian rise of ACTH.

    In plain wordsIn healthy men, a long oxytocin infusion did not delay the normal early-morning ACTH rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeTiming of circadian ACTH rise during oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  6. 06HumanNon-randomized trialEfficacy outcome

    In normal men, oxytocin pretreatment did not alter the plasma ACTH response to vasopressin.

    In plain wordsIn healthy men, oxytocin given beforehand did not change the ACTH response to vasopressin.

    Peptide
    Oxytocin
    Outcome
    No significant changeACTH response to vasopressin after oxytocin pretreatment
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    50 mU/kg bolus then 50 mU/kg per hour · ivAs given in this study (human).

    Source sentences

    Summary
    In addition, pretreatment with oxytocin (50 mU/kg, iv bolus dose, followed by an infusion of 50 mU/kg . h) did not alter the ACTH and cortisol responses to vasopressin.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  7. 07HumanNon-randomized trialEfficacy outcome

    In normal men, oxytocin pretreatment did not alter the plasma cortisol response to vasopressin.

    In plain wordsIn healthy men, oxytocin given beforehand did not change the cortisol response to vasopressin.

    Peptide
    Oxytocin
    Outcome
    No significant changeCortisol response to vasopressin after oxytocin pretreatment
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    50 mU/kg bolus then 50 mU/kg per hour · ivAs given in this study (human).

    Source sentences

    Summary
    In addition, pretreatment with oxytocin (50 mU/kg, iv bolus dose, followed by an infusion of 50 mU/kg . h) did not alter the ACTH and cortisol responses to vasopressin.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  8. 08HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not delay the normal circadian rise of cortisol.

    In plain wordsIn healthy men, a long oxytocin infusion did not delay the normal early-morning cortisol rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeTiming of circadian cortisol rise during oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
  9. 09HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not blunt the normal circadian rise of ACTH.

    In plain wordsIn healthy men, a long oxytocin infusion did not weaken the normal early-morning ACTH rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmplitude of circadian ACTH rise during oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.
  10. 10HumanNon-randomized trialEfficacy outcome

    In normal men, prolonged oxytocin infusion did not blunt the normal circadian rise of cortisol.

    In plain wordsIn healthy men, a long oxytocin infusion did not weaken the normal early-morning cortisol rise.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmplitude of circadian cortisol rise during oxytocin infusion
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    90 mU/kg per hour · 0300-0600 hAs given in this study (human).

    Source sentences

    Summary
    A prolonged infusion of oxytocin (90 mU/kg . h) given from 0300-0600 h did not suppress basal ACTH or cortisol levels or delay or blunt their normal circadian rise.
    1 context sentence
    Summary · context
    We studied the effect of oxytocin on plasma ACTH and cortisol in normal men under three conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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