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Study · Measured the body's own peptide · 1988

2 results

Differential effects of pituitary stalk-section on posterior pituitary and hypothalamic contents of prolactin-releasing factor, oxytocin, dopamine and beta-endorphin.

Hyde JF, Murai I, Ben-Jonathan N

Neuroendocrinology1 Sept 1988Cited by 10 (Europe PMC)

PMID2972937 (opens in a new tab)DOI10.1159/000125028 (opens in a new tab)PepBankPUB-02972937
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats, pituitary stalk section reduced oxytocin concentration in the posterior pituitary by more than 95% at 1 and 2 weeks.

    In plain wordsIn rats, cutting the pituitary stalk sharply lowered the body's own oxytocin in the back part of the pituitary.

    Peptide
    Oxytocin
    Outcome
    DecreasePosterior pituitary oxytocin concentration after stalk section
    Study

    Ratn: not reported in source

    Male rats with pituitary stalk section
    Comparator
    Sham surgery
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Reduction
    > 95%
    posterior pituitary, 1 and 2 weeks after stalk section

    Source sentences

    Summary
    OXY and DA concentrations in the posterior pituitary were reduced more than 95% at both 1 and 2 weeks after SS.
    1 context sentence
    Summary · context
    One or two weeks following pituitary SS or sham surgery (SHAM), acid extracts of the posterior pituitary and medial basal hypothalamus (MBH) were analyzed for their hormone content.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats, pituitary stalk section raised oxytocin levels in the medial basal hypothalamus by 123% at 1 week and 1,260% at 2 weeks versus sham surgery.

    In plain wordsIn rats, cutting the pituitary stalk raised the body's own oxytocin in the hypothalamus compared with sham surgery.

    Peptide
    Oxytocin
    Outcome
    IncreaseMedial basal hypothalamus oxytocin concentration after stalk section
    Study

    Ratn: not reported in source

    Male rats with pituitary stalk section
    Comparator
    Sham surgery
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Increase
    123%
    medial basal hypothalamus, 1 week
    Increase
    1260%
    medial basal hypothalamus, 2 weeks

    Source sentences

    Summary
    Unlike the posterior pituitary, OXY levels in the MBH increased 123% 1 week following SS, and 1,260% at 2 weeks.
    1 context sentence
    Summary · context
    One or two weeks following pituitary SS or sham surgery (SHAM), acid extracts of the posterior pituitary and medial basal hypothalamus (MBH) were analyzed for their hormone content.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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