Thymic factor-induced reduction of pulmonary metastases in mice with FSA-1 fibrosarcoma.

Tomazic VJ, Sacasa CR, Loftus A, Suter CS, Elias GE

Clinical & experimental metastasis1 Jan 1988Cited by 5 (Europe PMC)

PMID2961496DOI10.1007/bf01580403PepBankPUB-02961496

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice injected with fibrosarcoma cells, thymosin alpha‑1 at 0.1 micrograms per injection for two or three weeks prolonged survival.
In plain wordsIn mice with transplanted tumor cells, thymosin alpha‑1 injections prolonged survival.
Peptide
Thymosin alpha-1
Outcome
IncreaseSurvival of tumor-injected mice
Study
mousen: not reported in source
C3H/fSed male mice with FSA-1 fibrosarcoma pulmonary metastases
Outcome group
Tumor growth · Cancer
Studied dose
0.1 micrograms per injection · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
Treatment with 0.1 micrograms Ta-1 per injection through the period of two or three weeks, prolonged the survival of tumor-injected mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149601
02AnimalAnimal study (in vivo)Efficacy outcome
In mice injected with fibrosarcoma cells, thymosin alpha‑1 reduced the number of lung tumor colonies two weeks after cell injection compared with saline.
In plain wordsIn mice with transplanted tumor cells, thymosin alpha‑1 gave fewer lung tumor colonies than saline.
Peptide
Thymosin alpha-1
Outcome
DecreaseNumber of lung tumor colonies
Study
mousen: not reported in source
C3H/fSed male mice with FSA-1 fibrosarcoma pulmonary metastases
Comparator
Saline-treated controls
Outcome group
Tumor growth · Cancer
Studied dose
0.1 micrograms per injection · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
Numbers of tumor colonies in lungs of these mice two weeks after the cell injection were also reduced in comparison with saline-treated controls.
3 context sentences(design, population, supporting numbers)
Summary · context
Treatment with 0.1 micrograms Ta-1 per injection through the period of two or three weeks, prolonged the survival of tumor-injected mice.
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149602
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with fibrosarcoma, the effects induced by thymosin alpha‑1 persisted longer than those observed in thymulin-treated mice.
In plain wordsIn mice, the benefit of thymosin alpha‑1 lasted longer than the benefit of thymulin.
Peptide
Thymosin alpha-1
Outcome
IncreaseDuration of the anti-tumor effect versus thymulin
Study
mousen: not reported in source
C3H/fSed male mice with FSA-1 fibrosarcoma pulmonary metastases
Comparator
Thymulin
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the effects induced by Ta-1 persisted longer than observed in thymulin-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149603
04AnimalAnimal study (in vivo)Efficacy outcome
In mice rechallenged 150 days after the first tumor cell injection, thymosin alpha‑1 treatment gave increased resistance to tumor, while mice given other factors behaved as saline controls.
In plain wordsIn mice, thymosin alpha‑1 treatment led to more resistance when tumor cells were given again 150 days later, compared with saline.
Peptide
Thymosin alpha-1
Outcome
IncreaseResistance to tumor rechallenge at 150 days
Study
mousen: not reported in source
C3H/fSed male mice with FSA-1 fibrosarcoma pulmonary metastases
Comparator
Saline-treated controls
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
Mice challenged 150 days after the primary tumor cell injection and treatment with Ta-1 demonstrated increased resistance to tumor, while mice treated with other factors behaved as saline-treated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149604
05AnimalAnimal study (in vivo)Efficacy outcome
In tumor-injected mice, thymulin prolonged survival.
In plain wordsIn mice with tumors, thymulin prolonged survival.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSurvival
Study
mousen: not reported in source
C3H/fSed males with FSA-1 fibrosarcoma
Outcome group
Mortality · Cancer
Studied dose
0.01 microgram per injection · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Measurements
Thymulin dose
0.01 microgram
per injection
Source sentences
Summary
Similar effects were observed in mice treated with 0.01 microgram thymulin per injection.
3 context sentences(design, population, supporting numbers)
Summary · context
Treatment with 0.1 micrograms Ta-1 per injection through the period of two or three weeks, prolonged the survival of tumor-injected mice.
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149606
06AnimalAnimal study (in vivo)Efficacy outcome
In tumor-injected mice, thymulin reduced lung tumor colony numbers versus saline-treated controls.
In plain wordsIn mice with tumors, thymulin reduced lung tumor colonies compared with saline.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreasePulmonary tumor colonies
Study
mousen: not reported in source
C3H/fSed males with FSA-1 fibrosarcoma
Comparator
Saline-treated controls
Outcome group
Tumor growth · Cancer
Studied dose
0.01 microgram per injection · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
Numbers of tumor colonies in lungs of these mice two weeks after the cell injection were also reduced in comparison with saline-treated controls.
3 context sentences(design, population, supporting numbers)
Summary · context
Similar effects were observed in mice treated with 0.01 microgram thymulin per injection.
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149607
07AnimalAnimal study (in vivo)Efficacy outcome
In mice with fibrosarcoma, thymulin effects persisted for less time than thymosin alpha-1 effects.
In plain wordsIn mice with tumors, thymulin effects lasted less time than thymosin alpha-1 effects.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreasePersistence of antitumor effects
Study
mousen: not reported in source
C3H/fSed males with FSA-1 fibrosarcoma
Comparator
Thymosin alpha-1
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · subcutaneous · 2 or 3 weeksAs given in this study (mouse).
Source sentences
Summary
In addition, the effects induced by Ta-1 persisted longer than observed in thymulin-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
Report a problemFND-0296149609

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

08AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome
In mice with fibrosarcoma, the effectiveness of the thymic factors (thymulin and thymosin alpha‑1 together) in reducing tumor growth depended on the tumour load.
In plain wordsIn mice, how well the two thymic factors reduced tumor growth depended on how many tumor cells were given.
Peptide
Thymosin alpha-1
Outcome
Not applicableDependence of tumor-reducing effect on tumour load
Study
mousen: not reported in source
C3H/fSed male mice with FSA-1 fibrosarcoma pulmonary metastases
Outcome group
Tumor growth · Cancer
Source sentences
Summary
The effectiveness of thymic factors in reducing tumor growth was dependent on the tumour load.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0296149605
09AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome
In mice with fibrosarcoma, the tumor-growth effects of thymic factors, including thymulin, depended on tumor load.
In plain wordsIn mice with tumors, the effects of thymic factors, including thymulin, depended on tumor load.
Peptide
Thymulin (serum thymic factor)
Outcome
Direction not reportedTumor growth reduction by tumor load
Study
mousen: not reported in source
C3H/fSed males with FSA-1 fibrosarcoma
Outcome group
Tumor growth · Cancer
Source sentences
Summary
The effectiveness of thymic factors in reducing tumor growth was dependent on the tumour load.
3 context sentences(design, population, supporting numbers)
Summary · context
The biological activities of two thymic factors, serum thymic factor thymulin normally present in serum and thymosin alpha-1 (Ta-1) extracted from the thymus gland, have been studied.
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0296149608
10AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome
In mice challenged after initial treatment, factors other than Ta-1, including thymulin, produced responses similar to saline-treated controls.
In plain wordsIn mice challenged again, factors other than Ta-1, including thymulin, produced responses similar to saline-treated controls.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeResistance to tumor rechallenge
Study
mousen: not reported in source
C3H/fSed males with FSA-1 fibrosarcoma
Comparator
Saline-treated controls
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Mice challenged 150 days after the primary tumor cell injection and treatment with Ta-1 demonstrated increased resistance to tumor, while mice treated with other factors behaved as saline-treated controls.
3 context sentences(design, population, supporting numbers)
Summary · context
In addition, the effects induced by Ta-1 persisted longer than observed in thymulin-treated mice.
Summary · context
The effects of the factors on the growth of pulmonary metastases and survival of mice were evaluated in pathogen-free C3H/fSed males.
Summary · context
Different doses of the thymic factors were administered S.C. in sets of 5 daily injections through a period of 2 or 3 weeks.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0296149610

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 5 to 13Current
28 Oct 2026, 02:02 UTC
The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.
Study results updated
Version 4
21 Oct 2026, 12:50 UTC
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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