The rapid ovarian secretory response to pituitary stimulation by the gonadotropin-releasing hormone agonist nafarelin in sexual precocity.

Rosenfield RL, Garibaldi LR, Moll GW Jr, Watson AC, Burstein S

The Journal of clinical endocrinology and metabolism1 Dec 1986Cited by 12 (Europe PMC)

PMID2946712DOI10.1210/jcem-63-6-1386PepBankPUB-02946712

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialActivity measurement
In girls with precocious puberty, nafarelin produced faster and longer LH elevation than GnRH, with similar peaks.
In plain wordsIn girls with precocious puberty, nafarelin raised LH faster and longer than GnRH, with similar peaks.
Peptide
Nafarelin
Outcome
IncreaseLH response kinetics
Study
n = 13
Comparator
GnRH
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Source sentences
Summary
Although serum LH and FSH levels increased to similar peaks 3 h after commencing GnRH and nafarelin testing, they rose faster (P less than 0.01 at 1 h) and remained elevated longer (P less than 0.05 at 24 h) after nafarelin administration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671201
02HumanNon-randomized trialActivity measurement
In girls with precocious puberty, nafarelin produced faster and longer FSH elevation than GnRH, with similar peaks.
In plain wordsIn girls with precocious puberty, nafarelin raised FSH faster and longer than GnRH, with similar peaks.
Peptide
Nafarelin
Outcome
IncreaseFSH response kinetics
Study
n = 13
Comparator
GnRH
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Source sentences
Summary
Although serum LH and FSH levels increased to similar peaks 3 h after commencing GnRH and nafarelin testing, they rose faster (P less than 0.01 at 1 h) and remained elevated longer (P less than 0.05 at 24 h) after nafarelin administration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671202
03HumanNon-randomized trialActivity measurement
In girls with precocious puberty, estradiol rose from 30 +/- 6 to 115 +/- 13 pg/ml at 24 h after nafarelin.
In plain wordsIn girls with precocious puberty, estradiol increased from baseline at 24 h after nafarelin.
Peptide
Nafarelin
Outcome
IncreaseEstradiol at 24 hours
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Baseline estradiol
30 pg/ml
mean
Estradiol
115 pg/ml
24 h
Source sentences
Summary
However, plasma E2 increased later after nafarelin, but not after GnRH, rising from a baseline level of 30 +/- 6 (+/- SEM) to 115 +/- 13 pg/ml at 24 h (P less than 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671206
04HumanNon-randomized trialActivity measurement
In girls with precocious puberty, the least estradiol response to nafarelin at 24 h was 150%.
In plain wordsIn girls with precocious puberty, the least estradiol response to nafarelin at 24 h was 150%.
Peptide
Nafarelin
Outcome
IncreaseMinimum estradiol response
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Least estradiol response
150%
24 h
Source sentences
Summary
The least E2 response to nafarelin at this time was 150%.
3 context sentences(design, population, supporting numbers)
Summary · context
However, plasma E2 increased later after nafarelin, but not after GnRH, rising from a baseline level of 30 +/- 6 (+/- SEM) to 115 +/- 13 pg/ml at 24 h (P less than 0.001).
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671207
05HumanNon-randomized trialActivity measurement
In girls with precocious puberty, plasma levels of steroid intermediates in estradiol biosynthesis rose less than 2-fold after nafarelin, and only the androstenedione and estrone rises at 24 h were significant.
In plain wordsIn girls with precocious puberty, steroid intermediates after nafarelin rose less than 2-fold, and only androstenedione and estrone rises at 24 h were significant.
Peptide
Nafarelin
Outcome
IncreaseSteroid intermediate response
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Steroid intermediate fold rise
< 2 fold
intermediates in estradiol biosynthesis
Source sentences
Summary
That is, plasma levels of the intermediates in E2 biosynthesis rose less than 2-fold, and only the elevations in androstenedione, from 58 +/- 10 to 78 +/- 16 ng/dl (P less than 0.05), and estrone, from 14 +/- 3 to 38 +/- 7 pg/ml (P less than 0.02), at 24 h were significant.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671209
06HumanNon-randomized trialActivity measurement
In girls with precocious puberty, androstenedione rose from 58 +/- 10 to 78 +/- 16 ng/dl at 24 h after nafarelin (P less than 0.05).
In plain wordsIn girls with precocious puberty, androstenedione rose from baseline at 24 h after nafarelin.
Peptide
Nafarelin
Outcome
IncreaseAndrostenedione at 24 hours
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Baseline androstenedione
58 ng/dl
mean
Androstenedione
78 ng/dl
24 h
Source sentences
Summary
That is, plasma levels of the intermediates in E2 biosynthesis rose less than 2-fold, and only the elevations in androstenedione, from 58 +/- 10 to 78 +/- 16 ng/dl (P less than 0.05), and estrone, from 14 +/- 3 to 38 +/- 7 pg/ml (P less than 0.02), at 24 h were significant.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671210
07HumanNon-randomized trialActivity measurement
In girls with precocious puberty, estrone rose from 14 +/- 3 to 38 +/- 7 pg/ml at 24 h after nafarelin (P less than 0.02).
In plain wordsIn girls with precocious puberty, estrone rose from baseline at 24 h after nafarelin.
Peptide
Nafarelin
Outcome
IncreaseEstrone at 24 hours
Study
n = 13
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Baseline estrone
14 pg/ml
mean
Estrone
38 pg/ml
24 h
Source sentences
Summary
That is, plasma levels of the intermediates in E2 biosynthesis rose less than 2-fold, and only the elevations in androstenedione, from 58 +/- 10 to 78 +/- 16 ng/dl (P less than 0.05), and estrone, from 14 +/- 3 to 38 +/- 7 pg/ml (P less than 0.02), at 24 h were significant.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671211
08HumanNon-randomized trialActivity measurement
In sampled girls with precocious puberty, nafarelin produced a 6-fold estradiol response at 12 h.
In plain wordsIn sampled girls with precocious puberty, nafarelin produced a 6-fold estradiol response at 12 h.
Peptide
Nafarelin
Outcome
IncreaseEstradiol at 12 hours
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.2 microgram/kg · subcutaneousAs given in this study (human).
Measurements
Estradiol response
6 fold
12 h, patients sampled then
Source sentences
Summary
This rise is probably an underestimate of the maximum E2 rise, since a 6-fold response to nafarelin was found at 12 h in patients sampled then.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
Report a problemFND-0294671208

Studies that did not test the peptide alone2

In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Nafarelin.

09HumanNot a test of Nafarelin aloneNon-randomized trialActivity measurement
In girls with precocious puberty, at the third hour of testing with either nafarelin or GnRH, LH rose 8.8-fold versus baseline.
In plain wordsIn girls with precocious puberty, LH rose 8.8-fold from baseline at the third hour of testing with either nafarelin or GnRH.
Peptide
Nafarelin
Outcome
IncreaseLH at third hour
Study
n = 13
Comparator
Baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
LH fold rise
8.8 fold
third hour, either agent
Source sentences
Summary
At the third hour of testing with either agent, LH and FSH rose 8.8- and 3.4-fold, respectively (P less than 0.001 vs. baseline), whereas the rise in E2 was inconsistent and averaged only one third (P less than 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nafarelin.
Report a problemFND-0294671203
10HumanNot a test of Nafarelin aloneNon-randomized trialActivity measurement
In girls with precocious puberty, at the third hour of testing with either nafarelin or GnRH, FSH rose 3.4-fold versus baseline.
In plain wordsIn girls with precocious puberty, FSH rose 3.4-fold from baseline at the third hour of testing with either nafarelin or GnRH.
Peptide
Nafarelin
Outcome
IncreaseFSH at third hour
Study
n = 13
Comparator
Baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
FSH fold rise
3.4 fold
third hour, either agent
Source sentences
Summary
At the third hour of testing with either agent, LH and FSH rose 8.8- and 3.4-fold, respectively (P less than 0.001 vs. baseline), whereas the rise in E2 was inconsistent and averaged only one third (P less than 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated a GnRH agonist (GnRHa) as a potential single stimulus to both pituitary and ovarian secretion in 13 girls with true precocious puberty.
Summary · context
We compared the GnRH agonist [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as a single sc injection of 0.2 microgram/kg to GnRH infused iv in a dose of 2 micrograms/kg X h for 3 h and assessed the response of plasma steroid intermediates in estradiol (E2) biosynthesis.
In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nafarelin.
Report a problemFND-0294671204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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