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Study · Animal study (in vivo) · mouse · 1986

4 results

Reconstitution of T cell functions in aging mice by thymosin alpha 1.

Frasca D, Adorini L, Mancini C, Doria G

Immunopharmacology1 Jun 1986Cited by 36 (Europe PMC)

PMID2942521 (opens in a new tab)DOI10.1016/0162-3109(86)90017-2 (opens in a new tab)PepBankPUB-02942521
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aging BDF1 mice, injection of thymosin alpha‑1 largely restored the impaired helper T cell activity of spleen cells.

    In plain wordsIn aging mice, thymosin alpha‑1 largely restored weakened helper T cell activity.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseHelper T cell activity of spleen cells in old mice
    Study

    mousen: not reported in source

    Aging BDF1 mice (old 6-18 months, young 3 months)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Helper T cell activity of spleen cells from BDF1 mice is impaired by aging but is restored to a large extent by injection of thymosin alpha 1
  2. 02AnimalAnimal study (in vivo)Mechanism

    In old mice, injection of thymosin alpha‑1 enhanced interleukin-2 production by mitogen-activated spleen cells.

    In plain wordsIn old mice, thymosin alpha‑1 increased interleukin-2 production by activated spleen cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseInterleukin-2 production by mitogen-activated spleen cells from old mice
    Study

    mousen: not reported in source

    Aging BDF1 mice (old 6-18 months, young 3 months)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    the observed enhancement of interleukin-2 production by mitogen-activated spleen cells from old mice upon injection of thymosin alpha 1
  3. 03AnimalAnimal study (in vivo)Mechanism

    In old mice, injection of thymosin alpha‑1 enhanced interleukin-2 receptor expression on mitogen-activated spleen cells.

    In plain wordsIn old mice, thymosin alpha‑1 increased interleukin-2 receptor levels on activated spleen cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseInterleukin-2 receptor expression on spleen cells from old mice
    Study

    mousen: not reported in source

    Aging BDF1 mice (old 6-18 months, young 3 months)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    injection of thymosin alpha 1, or its N14, but not C14, fragment enhances the expression of interleukin-2 receptors on mitogen-activated spleen cells from old but not from young mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In young mice, thymosin alpha‑1 did not enhance interleukin-2 receptor expression on mitogen-activated spleen cells.

    In plain wordsIn young mice, thymosin alpha‑1 did not raise interleukin-2 receptor levels on activated spleen cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeInterleukin-2 receptor expression on spleen cells from young mice
    Study

    mousen: not reported in source

    Aging BDF1 mice (old 6-18 months, young 3 months)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    injection of thymosin alpha 1, or its N14, but not C14, fragment enhances the expression of interleukin-2 receptors on mitogen-activated spleen cells from old but not from young mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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