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Study · Ex vivo tissue · 1986

2 results

Thymosin effects on immunoglobulin synthesis and suppressor T cell activity in normal subjects and patients with primary biliary cirrhosis.

Kilby AE, Krawitt EL

International journal of immunopharmacology1 Jan 1986

PMID2937748 (opens in a new tab)DOI10.1016/0192-0561(86)90080-9 (opens in a new tab)PepBankPUB-02937748
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In lymphocytes from patients with primary biliary cirrhosis, thymosin alpha‑1 enhanced the lower pokeweed-stimulated IgG and IgM synthesis seen versus normals, so the deficit became larger.

    In plain wordsIn lab tests on blood cells from donors with biliary cirrhosis, thymosin alpha‑1 made their already low antibody production lower, not higher.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePokeweed-stimulated IgG and IgM synthesis in primary biliary cirrhosis lymphocytes
    Study

    humann: not reported in source

    Peripheral blood lymphocytes
    Comparator
    Lymphocytes from normal subjects
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Lymphocytes from patients with PBC synthesized less IgG and IgM than normals when stimulated by pokeweed mitogen, and this difference was enhanced by both thymosin fraction 5 and thymosin alpha 1.
    1 context sentence
    Summary · context
    To determine whether thymic hormone preparations reverse these immunologic defects in vitro, the effects of thymosin fraction 5 and thymosin alpha 1 on immunoglobulin synthesis and concanavalin A-induced suppression of immunoglobulin synthesis were investigated in normal subjects and patients with p…

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 02LabNot a test of Thymosin alpha-1 aloneEx vivo tissueEfficacy outcome

    In lymphocytes from normal subjects, thymosin (thymosin fraction 5 and thymosin alpha‑1 were tested) had no effect on unstimulated or pokeweed-stimulated immunoglobulin synthesis or on Con A-induced suppressor cell activity.

    In plain wordsIn lab tests on blood cells from healthy donors, thymosin fraction 5 and thymosin alpha‑1 did not change antibody production or suppressor cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeImmunoglobulin synthesis and suppressor cell activity in normal subjects
    Study

    humann: not reported in source

    Peripheral blood lymphocytes
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    In normal subjects, no effects of thymosin were observed on unstimulated and pokeweed mitogen-stimulated immunoglobulin synthesis, nor on Con A-induced suppressor cell activity.
    1 context sentence
    Summary · context
    To determine whether thymic hormone preparations reverse these immunologic defects in vitro, the effects of thymosin fraction 5 and thymosin alpha 1 on immunoglobulin synthesis and concanavalin A-induced suppression of immunoglobulin synthesis were investigated in normal subjects and patients with p…

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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