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Study · Animal study (in vivo) · mouse · 1985

3 results

Enhancement of helper and suppressor T cell activities by thymosin alpha 1 injection in old mice.

Frasca D, Adorini L, Doria G

Immunopharmacology1 Aug 1985Cited by 14 (Europe PMC)

PMID2932410 (opens in a new tab)DOI10.1016/0162-3109(85)90058-x (opens in a new tab)PepBankPUB-02932410
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immunodeficient old BDF1 mice, a single injection of synthetic thymosin alpha‑1 before priming enhanced the helper activity of spleen cells.

    In plain wordsIn old mice, one injection of thymosin alpha‑1 raised the helper activity of spleen immune cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseHelper activity of spleen cells in old mice
    Study

    mousen: not reported in source

    BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1-100 microgramsAs given in this study (mouse).

    Source sentences

    Summary
    A single injection of immunodeficient old (15-24 month old) BDF1 mice with 1-100 micrograms of synthetic thymosin alpha 1 (T alpha 1), a 28-amino acid residue peptide, shortly before horse erythrocyte (HRBC)-priming, enhances the helper activity of their spleen cells.
    1 context sentence
    Summary · context
    As evaluated from the in vitro anti-TNP antibody response, spleen cells exhibit higher helper activity when derived from T alpha 1-injected, as compared to uninjected, HRBC-primed old mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young mice, injection of thymosin alpha‑1 before priming had no effect.

    In plain wordsIn young mice, thymosin alpha‑1 injection had no effect on this immune measure.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeHelper activity of spleen cells in young mice
    Study

    mousen: not reported in source

    BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No effect is observed when T alpha 1 is injected in young mice before HRBC-priming.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old mice, thymosin alpha‑1 injection restored helper activity to levels comparable to helper cells from young mice.

    In plain wordsIn old mice, thymosin alpha‑1 brought helper immune cell activity back to levels seen in young mice.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRestoration of helper activity in old mice to young levels
    Study

    mousen: not reported in source

    BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Injection of T alpha 1 or the N14 fragment restores the helper activity of old mice to levels comparable to that displayed by helper cells from young mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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