Skip to content

Study · Animal study (in vivo) · dog · 1985

14 results

Long-term reversible suppression of oestrus in bitches with nafarelin acetate, a potent LHRH agonist.

McRae GI, Roberts BB, Worden AC, Bajka A, Vickery BH

Journal of reproduction and fertility1 Jul 1985Cited by 19 (Europe PMC)

PMID2931517 (opens in a new tab)DOI10.1530/jrf.0.0740389 (opens in a new tab)PepBankPUB-02931517
Source linkPubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 3 beagle bitches, no new oestrus occurred during 18 months of nafarelin treatment.

    In plain wordsIn dogs, no new oestrus occurred in 3 bitches during 18 months of nafarelin treatment.

    Peptide
    Nafarelin
    Outcome
    DecreaseNew oestrus during treatment
    Study

    dogn = 3

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    32 micrograms/day · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    No new oestrus was detected in 3 bitches during 18 months of treatment with 32 micrograms/day, which resulted in mean plasma levels of 0.4 ng analogue/ml.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In 3 beagle bitches, nafarelin produced mean plasma levels of 0.4 ng/ml.

    In plain wordsIn dogs, nafarelin produced mean plasma levels of 0.4 ng/ml.

    Peptide
    Nafarelin
    Outcome
    Not applicablePlasma nafarelin
    Study

    dogn = 3

    beagle bitches
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    32 micrograms/day · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    No new oestrus was detected in 3 bitches during 18 months of treatment with 32 micrograms/day, which resulted in mean plasma levels of 0.4 ng analogue/ml.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In all 3 beagle bitches, oestrus returned 3 to 18 weeks after nafarelin cessation.

    In plain wordsIn dogs, oestrus returned in all 3 bitches 3 to 18 weeks after nafarelin stopped.

    Peptide
    Nafarelin
    Outcome
    Not applicableReturn to oestrus
    Study

    dogn = 3

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    32 micrograms/day · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    A return to oestrus was observed in all 3 bitches between 3 and 18 weeks after cessation of treatment: 2 of the bitches mated at those times and produced normal litters.
    2 context sentences
    Summary · context
    No new oestrus was detected in 3 bitches during 18 months of treatment with 32 micrograms/day, which resulted in mean plasma levels of 0.4 ng analogue/ml.
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In 3 beagle bitches mated at nafarelin-induced heat, continued treatment through gestation produced no litters.

    In plain wordsIn dogs, 3 bitches mated at nafarelin-induced heat produced no litters during continued treatment.

    Peptide
    Nafarelin
    Outcome
    Not applicableLitter production after induced heat
    Study

    dogn = 3

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pump · normal duration of gestationAs given in this study (dog).

    Source sentences

    Summary
    Three bitches mated at the induced heat and treated for the normal duration of gestation did not litter.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In 3 prepubertal beagle bitches, nafarelin did not induce signs of oestrus.

    In plain wordsIn dogs, nafarelin did not induce oestrus signs in 3 prepubertal bitches.

    Peptide
    Nafarelin
    Outcome
    No significant changePrepubertal oestrus induction
    Study

    dogn = 3

    prepubertal beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    Nafarelin treatment of 3 bitches before puberty did not induce signs of oestrus and prevented the occurrence of oestrus through 18 months of treatment.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In 3 prepubertal beagle bitches, nafarelin prevented oestrus through 18 months of treatment.

    In plain wordsIn dogs, nafarelin prevented oestrus in 3 prepubertal bitches through 18 months of treatment.

    Peptide
    Nafarelin
    Outcome
    DecreasePrepubertal oestrus prevention
    Study

    dogn = 3

    prepubertal beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    Nafarelin treatment of 3 bitches before puberty did not induce signs of oestrus and prevented the occurrence of oestrus through 18 months of treatment.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In beagle bitches treated before puberty, first oestrus occurred 3.5-4 months after nafarelin cessation.

    In plain wordsIn dogs treated before puberty, first oestrus occurred 3.5-4 months after nafarelin stopped.

    Peptide
    Nafarelin
    Outcome
    Not applicablePost-prepubertal treatment oestrus
    Study

    dogn = 3

    beagle bitches treated before puberty
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    The first oestrus in these bitches occurred 3.5-4 months after cessation of treatment, but mating at that time did not result in pregnancy.
    2 context sentences
    Summary · context
    Nafarelin treatment of 3 bitches before puberty did not induce signs of oestrus and prevented the occurrence of oestrus through 18 months of treatment.
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In beagle bitches, 2 mated after nafarelin cessation and produced normal litters.

    In plain wordsIn dogs, 2 bitches mated after nafarelin stopped and produced normal litters.

    Peptide
    Nafarelin
    Outcome
    Not applicablePost-treatment normal litters
    Study

    dogn = 2

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    32 micrograms/day · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    A return to oestrus was observed in all 3 bitches between 3 and 18 weeks after cessation of treatment: 2 of the bitches mated at those times and produced normal litters.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In 2 beagle bitches mated at treatment initiation, one conceived and produced a normal litter during nafarelin treatment.

    In plain wordsIn dogs, one of 2 bitches mated at nafarelin initiation conceived and produced a normal litter.

    Peptide
    Nafarelin
    Outcome
    Not applicableConception and normal litter during treatment
    Study

    dogn = 2

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    32 micrograms/day · subcutaneous osmotic pump · about 63 daysAs given in this study (dog).

    Source sentences

    Summary
    One of the bitches conceived and produced a normal litter.
    2 context sentences
    Summary · context
    Another 2 bitches were similarly treated with 32 micrograms analogue/day; they were mated at the oestrus at start of treatment and dosing was continued for about 63 days.
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In cyclic beagle bitches, nafarelin appeared not to affect imminent ovulation.

    In plain wordsIn dogs, nafarelin appeared not to affect imminent ovulation.

    Peptide
    Nafarelin
    Outcome
    No significant changeImminent ovulation
    Study

    dogn: not reported in source

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pumpAs given in this study (dog).

    Source sentences

    Summary
    The imminent ovulation appeared to be unaffected by treatment, but doses of 8 or 32 micrograms analogue/day reduced the integrated luteal progesterone values.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In cyclic beagle bitches, nafarelin at 8 micrograms/day reduced integrated luteal progesterone.

    In plain wordsIn dogs, nafarelin at 8 micrograms/day reduced integrated luteal progesterone.

    Peptide
    Nafarelin
    Outcome
    DecreaseIntegrated luteal progesterone
    Study

    dogn: not reported in source

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    8 micrograms/day · subcutaneous osmotic pumpAs given in this study (dog).

    Source sentences

    Summary
    The imminent ovulation appeared to be unaffected by treatment, but doses of 8 or 32 micrograms analogue/day reduced the integrated luteal progesterone values.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In cyclic beagle bitches, nafarelin at 32 micrograms/day reduced integrated luteal progesterone.

    In plain wordsIn dogs, nafarelin at 32 micrograms/day reduced integrated luteal progesterone.

    Peptide
    Nafarelin
    Outcome
    DecreaseIntegrated luteal progesterone
    Study

    dogn: not reported in source

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    32 micrograms/day · subcutaneous osmotic pumpAs given in this study (dog).

    Source sentences

    Summary
    The imminent ovulation appeared to be unaffected by treatment, but doses of 8 or 32 micrograms analogue/day reduced the integrated luteal progesterone values.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In anoestrous beagle bitches, nafarelin induced heat within 1-2 weeks, with vaginal discharge, oestrous cytology, and progesterone evidence of ovulation.

    In plain wordsIn dogs without oestrus, nafarelin induced heat 1-2 weeks after treatment began.

    Peptide
    Nafarelin
    Outcome
    IncreaseHeat induction during anoestrus
    Study

    dogn: not reported in source

    beagle bitches
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pumpAs given in this study (dog).

    Source sentences

    Summary
    Nafarelin acetate treatment begun during anoestrus resulted in an induced heat 1-2 weeks after the start of treatment.
    2 context sentences
    Summary · context
    The induced heat consisted of pro-oestrous vaginal discharge, oestrous vaginal cytology, and ovulation (judged by increased circulating levels of progesterone).
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In beagle bitches treated before puberty, mating at first oestrus after nafarelin cessation did not produce pregnancy.

    In plain wordsIn dogs treated before puberty, mating at first oestrus after nafarelin stopped did not produce pregnancy.

    Peptide
    Nafarelin
    Outcome
    Not applicablePregnancy at first post-treatment oestrus
    Study

    dogn: not reported in source

    beagle bitches treated before puberty
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous osmotic pump · 18 monthsAs given in this study (dog).

    Source sentences

    Summary
    The first oestrus in these bitches occurred 3.5-4 months after cessation of treatment, but mating at that time did not result in pregnancy.
    1 context sentence
    Summary · context
    Adult cyclic beagle bitches were treated for up to 18 months with nafarelin acetate via subcutaneously implanted osmotic pumps, starting during the first week of a pro-oestrous vaginal discharge.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.