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Study · Animal study (in vivo) · rat · 1988

2 results

Antiamnesic effects of D-pipecolic acid and analogues of Pro-Leu-Gly-NH2 in rats.

Kovács GL, Szabó G, Telegdy G, Baláspiri L, Pálos E, Szpornyi L

Pharmacology, biochemistry, and behavior1 Dec 1988Cited by 7 (Europe PMC)

PMID2908068 (opens in a new tab)DOI10.1016/0091-3057(88)90392-9 (opens in a new tab)PepBankPUB-02908068
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG attenuated electroconvulsive shock-induced retrograde amnesia in a dose-dependent manner.

    In plain wordsIn rats, PLG reduced memory loss after electroconvulsive shock in a dose-dependent manner.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseRetrograde amnesia
    Study

    ratn: not reported in source

    electroconvulsive shock-induced retrograde amnesia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PLG resulted in dose-dependent attenuation of retrograde amnesia.
    2 context sentences
    Summary · context
    The antiamnesic effects of prolyl-leucyl-glycinamide (PLG) and analogues of this tripeptide were investigated in rats.
    Summary · context
    Retrograde amnesia was induced by electroconvulsive shock treatment and the degree of amnesia was characterized by the attenuation of one-trial learning passive avoidance response.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG was less effective against amnesia than some tripeptides containing D-pipecolic acid instead of N-terminal proline.

    In plain wordsIn rats, PLG reduced amnesia less than some tripeptides that replaced its starting proline with D-pipecolic acid.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseAntiamnesic efficacy versus D-pipecolic acid tripeptides
    Study

    ratn: not reported in source

    electroconvulsive shock-induced retrograde amnesia
    Comparator
    tripeptides containing D-pipecolic acid instead of N-terminal proline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Some tripeptides, all of them containing D-pipecolic acid instead of the N-terminal proline, were more effective than PLG.
    2 context sentences
    Summary · context
    The antiamnesic effects of prolyl-leucyl-glycinamide (PLG) and analogues of this tripeptide were investigated in rats.
    Summary · context
    Retrograde amnesia was induced by electroconvulsive shock treatment and the degree of amnesia was characterized by the attenuation of one-trial learning passive avoidance response.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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