Synergism and diurnal variations of human growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves.

Lapierre H, Petitclerc D, Pelletier G, Dubreuil P, Morisset J, Gaudreau P, Couture Y, Brazeau P

Domestic animal endocrinology1 Oct 1987Cited by 4 (Europe PMC)

PMID2907311DOI10.1016/0739-7240(87)90017-8PepBankPUB-02907311

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In calves exposed to 16 h of light, intravenous hGRF(1-29)NH2 alone gave an average GH peak of 49.7 ng/ml and an area under the GH curve of 1247 ng/ml.min.
In plain wordsIn dairy calves, injection of this peptide alone gave an average growth hormone peak of 49.7 ng/ml.
Peptide
Sermorelin
Outcome
Direction not reportedGH peak and AUC after hGRF(1-29)NH2 alone (16L:8D)
Study
dairy calves (Holstein)n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.22 micrograms/kg body weight · intravenousAs given in this study (dairy calves (Holstein)).
Measurements
GH peak
49.7 ng/ml
hGRF(1-29)NH2 alone, 16L:8D
GH AUC
1247 ng/ml.min
hGRF(1-29)NH2 alone, 16L:8D
Source sentences
Summary
In animals exposed to 16L:8D, average GH peaks reached after hGRF (1-29)NH2 or TRF injections were 49.7 and 32.0 ng/ml while the area under the GH response curve (AUC) were 1247 and 1019 ng/ml.min, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen male Holstein calves averaging 168 kg body weight (BW)
Report a problemFND-0290731101
02AnimalAnimal study (in vivo)Efficacy outcome
In calves, time of injection had no significant effect on GH release after separate injection of hGRF(1-29)NH2.
In plain wordsIn dairy calves, the time of day of the peptide injection made no significant difference to growth hormone release.
Peptide
Sermorelin
Outcome
No significant changeGH release by time of injection after hGRF(1-29)NH2 alone
Study
dairy calves (Holstein)n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.22 micrograms/kg body weight · intravenousAs given in this study (dairy calves (Holstein)).
Source sentences
Summary
There was no significant effect of times of injection on GH release following the separate injection of hGRF(1-29)NH2 or TRF.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen male Holstein calves averaging 168 kg body weight (BW)
Report a problemFND-0290731102

Studies that did not test the peptide alone2

In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Sermorelin.

03AnimalNot a test of Sermorelin aloneAnimal study (in vivo)Efficacy outcome
In calves exposed to 16 h of light, GH peaks and AUC after hGRF plus TRF were high at 0400, 1000 and 1600 hr (lights on) but only 42.3 ng/ml and 1692 ng/ml.min at 2200 hr (lights off).
In plain wordsIn dairy calves, the growth hormone response to the peptide plus TRF was large when lights were on and small when lights were off.
Peptide
Sermorelin
Outcome
MixedDiurnal GH peak and AUC after hGRF plus TRF (16L:8D)
Study
dairy calves (Holstein)n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
226.4 ng/ml
0400 hr
GH peak
189.2 ng/ml
1000 hr
GH peak
116.8 ng/ml
1600 hr
GH peak
42.3 ng/ml
2200 hr
GH AUC
4340 ng/ml.min
0400 hr
GH AUC
3660 ng/ml.min
1000 hr
GH AUC
2415 ng/ml.min
1600 hr
GH AUC
1692 ng/ml.min
2200 hr
Source sentences
Summary
In animals exposed to 16L:8D, GH peaks and AUC after hGRF plus TRF injections were 226.4, 189.2 and 116.8 ng/ml, and 4340, 3660 and 2415 ng/ml.min at 0400, 1000 and 1600 hr (lights on), respectively but only 42.3 ng/ml and 1692 ng/ml.min at 2200 hr (lights off).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen male Holstein calves averaging 168 kg body weight (BW)
In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.
Report a problemFND-0290731103
04AnimalNot a test of Sermorelin aloneAnimal study (in vivo)Efficacy outcome
In calves exposed to 8 h of light, GH levels and AUC after hGRF plus TRF were high at 1000 and 1600 hr (lights on) and lower at 0400 and 2200 hr (lights off).
In plain wordsIn dairy calves on a short-light schedule, the growth hormone response to the peptide plus TRF was larger when lights were on.
Peptide
Sermorelin
Outcome
MixedDiurnal GH peak and AUC after hGRF plus TRF (8L:16D)
Study
dairy calves (Holstein)n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
177.5 ng/ml
1000 hr
GH peak
180.5 ng/ml
1600 hr
GH peak
84 ng/ml
0400 hr
GH peak
72.7 ng/ml
2200 hr
GH AUC
2759 ng/ml.min
1000 hr
GH AUC
3704 ng/ml.min
1600 hr
GH AUC
1544 ng/ml.min
0400 hr
GH AUC
1501 ng/ml.min
2200 hr
Source sentences
Summary
In animals exposed to 8L:16D, GH levels and AUC after hGRF plus TRF injections reached 177.5 and 180.5 ng/ml, and 2759 and 3704 ng/ml.min at 1000 and 1600 hr (lights on) but only 84.0 and 72.7 ng/ml, and 1544 and 1501 ng/ml.min at 0400 and 2200 hr (lights off), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen male Holstein calves averaging 168 kg body weight (BW)
In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.
Report a problemFND-0290731104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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