A comparison of the differential effects of vasoactive intestinal peptide and peptide histidine isoleucine on the vascular and capsular smooth muscle of the dog spleen.

Corder R, Withrington PG

British journal of pharmacology1 Oct 1988Cited by 7 (Europe PMC)

PMID2906563PMCIDPMC1854169DOI10.1111/j.1476-5381.1988.tb11689.xPepBankPUB-02906563

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In the isolated dog spleen, intra-arterial VIP caused graded increases in splenic arterial blood flow at constant perfusion pressure, indicating vasodilatation.
In plain wordsIn lab tests on dog spleen, VIP widened the spleen's arteries and raised blood flow.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSplenic arterial blood flow
Study
dogn: not reported in source
Isolated blood-perfused spleen
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
Intra-arterial injections of VIP and PHI caused graded increases in splenic arterial blood flow at constant perfusion pressure indicative of splenic arterial vasodilatation.
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656301
02LabEx vivo tissueActivity measurement
In the isolated dog spleen, VIP was significantly more potent than PHI as a splenic vasodilator.
In plain wordsIn lab tests on dog spleen, VIP widened blood vessels at a much lower dose than PHI.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicablePotency of VIP versus PHI
Study
dogn: not reported in source
Isolated blood-perfused spleen
Comparator
Peptide histidine isoleucine
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Measurements
ED50
9.9 pmol
VIP
Source sentences
Summary
VIP was significantly more potent than PHI, with their respective molar ED50 values being 9.9 +/- 3.7 and 830 +/- 141 pmol (P less than 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656302
03LabEx vivo tissueActivity measurement
In the isolated dog spleen, VIP was approximately 10 times more potent than isoprenaline as a splenic vasodilator.
In plain wordsIn lab tests on dog spleen, VIP widened blood vessels at a lower dose than isoprenaline did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicablePotency of VIP versus isoprenaline
Study
dogn: not reported in source
Isolated blood-perfused spleen
Comparator
Isoprenaline
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Measurements
relative potency versus isoprenaline
≈ 10-fold
VIP
Source sentences
Summary
VIP was approximately 10 and 200 times more potent than isoprenaline and PHI respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656303
04LabEx vivo tissueActivity measurement
In the isolated dog spleen, the maximum reduction in splenic vascular resistance with VIP was the same as with PHI.
In plain wordsIn lab tests on dog spleen, VIP and PHI lowered blood vessel resistance by the same maximum amount.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMaximum reduction in splenic arterial vascular resistance versus PHI
Study
dogn: not reported in source
Isolated blood-perfused spleen
Comparator
Peptide histidine isoleucine
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
The maximum reduction in splenic arterial vascular resistance was the same (P greater than 0.5) in response to intra-arterial VIP and PHI
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656304
05LabEx vivo tissueActivity measurement
In the isolated dog spleen, the maximum reduction in splenic vascular resistance with VIP was significantly less than with isoprenaline.
In plain wordsIn lab tests on dog spleen, VIP lowered blood vessel resistance by less than isoprenaline did at its maximum.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMaximum reduction in splenic arterial vascular resistance versus isoprenaline
Study
dogn: not reported in source
Isolated blood-perfused spleen
Comparator
Isoprenaline
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
although both peptide maxima were significantly less (P less than 0.05, 0.01 respectively) than that obtained with isoprenaline.
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656305
06LabEx vivo tissueActivity measurement
In the isolated dog spleen, VIP was accompanied by small increases in spleen volume, probably passive and secondary to arterial vasodilatation.
In plain wordsIn lab tests on dog spleen, VIP came with small rises in spleen size, probably a side effect of wider arteries.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSpleen volume
Study
dogn: not reported in source
Isolated blood-perfused spleen
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
Small increases in spleen volume accompanied the splenic vasodilator responses to both peptides. They were probably passive in origin, secondary to splenic arterial vasodilatation.
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656306
07LabEx vivo tissueMechanism
In the isolated dog spleen, the beta 2-adrenoceptor antagonist ICI 118,551 did not antagonize the splenic arterial vasodilator response to VIP.
In plain wordsIn lab tests on dog spleen, a beta 2 blocker did not stop VIP from widening blood vessels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeEffect of beta 2-adrenoceptor antagonist ICI 118,551 on VIP vasodilator response
Study
dogn: not reported in source
Isolated blood-perfused spleen
Comparator
ICI 118,551
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · intra-arterialAs given in this study (dog).
Source sentences
Summary
The selective beta 2-adrenoceptor antagonist, ICI 118,551, did not antagonize the splenic arterial vasodilator response to VIP or PHI but markedly attenuated the effect of isoprenaline.
1 context sentence(design, population, supporting numbers)
Summary · context
The actions of the two peptides, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) have been compared to that of isoprenaline on the smooth muscle systems of the isolated blood-perfused dog spleen.
Report a problemFND-0290656307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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