Astrocytes from forebrain, cerebellum, and spinal cord differ in their responses to vasoactive intestinal peptide.

Cholewinski AJ, Wilkin GP

Journal of neurochemistry1 Nov 1988Cited by 54 (Europe PMC)

PMID2902198DOI10.1111/j.1471-4159.1988.tb01133.xPepBankPUB-02902198

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In rat cortical astrocytes, VIP increased intracellular cAMP 180-fold, as much as isoproterenol (185-fold).
In plain wordsIn rat brain cortex cells, VIP raised the cell signal cAMP strongly, about as much as isoproterenol did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP response in cortical astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
cAMP increase
180-fold
cortical astrocytes, VIP
Source sentences
Summary
The response to VIP was as great as that to isoproterenol in cortical astrocytes (180-fold and 185-fold, respectively)
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
Report a problemFND-0290219801
02LabIn vitro (cells)Activity measurement
In rat spinal cord astrocytes, VIP raised cAMP seven- to ninefold, a much smaller response than in cortex.
In plain wordsIn rat spinal cord cells, VIP raised the cell signal cAMP, but much less than in cortex cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP response in spinal cord astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Spinal cord astrocytes also responded to VIP and isoproterenol with equal potency (seven- to ninefold and eight- to 13-fold, respectively), but the level of response was much smaller than in cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
Report a problemFND-0290219802
03LabIn vitro (cells)Activity measurement
In rat cerebellar astrocytes, VIP raised cAMP only threefold, the lowest of the three regions.
In plain wordsIn rat cerebellum cells, VIP raised the cell signal cAMP only a little, less than in the other two regions.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP response in cerebellar astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The response to VIP was lowest in cerebellar astrocytes (only threefold)
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
Report a problemFND-0290219803

Studies that did not test the peptide alone3

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Activity measurement
In rat cortical astrocytes, VIP combined with isoproterenol had a partially additive effect on cAMP.
In plain wordsIn rat brain cortex cells, VIP together with isoproterenol gave a partly additive rise in the cell signal cAMP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedVIP plus isoproterenol in cortical astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
and the effect of VIP in combination with isoproterenol was partially additive.
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0290219804
05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Activity measurement
In rat spinal cord astrocytes, VIP and isoproterenol together acted synergistically on cAMP.
In plain wordsIn rat spinal cord cells, VIP together with isoproterenol gave a stronger response than expected from each alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP plus isoproterenol in spinal cord astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Spinal cord astrocytes were synergistic in their response to VIP and isoproterenol.
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0290219805
06LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Activity measurement
In rat cerebellar astrocytes, no additivity was seen when VIP was added together with isoproterenol.
In plain wordsIn rat cerebellum cells, adding VIP together with isoproterenol gave no added effect.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP plus isoproterenol in cerebellar astrocytes
Study
ratn: not reported in source
Astrocytes from cortex, cerebellum and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
and no additivity was observed when VIP was added together with isoproterenol.
1 context sentence(design, population, supporting numbers)
Summary · context
The results from the above study show that astrocytes obtained from these three regions of the rat CNS express quite different responses to VIP and alpha-MSH and further point to possible astrocyte heterogeneity.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0290219806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.