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Study · Not a test of the peptide alone · 1987

3 results

GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: studies with pyridostigmine and GHRH.

Ross RJ, Tsagarakis S, Grossman A, Nhagafoong L, Touzel RJ, Rees LH, Besser GM

Clinical endocrinology1 Dec 1987Cited by 67 (Europe PMC)

PMID2901302 (opens in a new tab)DOI10.1111/j.1365-2265.1987.tb02957.x (opens in a new tab)PepBankPUB-02901302
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Sermorelin.

  1. 01HumanNot a test of Sermorelin aloneNon-randomized trialEfficacy outcome

    In six healthy men, oral pyridostigmine augmented the growth hormone response to intravenous GHRH(1-29)NH2 by more than the additive effect of each agent alone.

    In plain wordsIn six healthy men, the drug pyridostigmine made the growth hormone response to a GHRH injection larger than the two agents added together.

    Peptide
    Sermorelin
    Outcome
    IncreaseGH response to GHRH(1-29)NH2 with pyridostigmine
    Study

    n = 6

    Comparator
    Each agent alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In six healthy male adult volunteers 120 mg oral pyridostigmine increased basal GH secretion compared to placebo and augmented the GH response to 100 micrograms i.v. GHRH (1-29) NH2; the effect was more than the additive effect of pyridostigmine and GHRH when each was given alone.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  2. 02HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy men, pretreatment with methionyl-hGH abolished the serum GH response to GHRH given 3 h later.

    In plain wordsIn healthy men, a prior growth hormone dose removed the growth hormone response to a later GHRH injection.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH response to GHRH(1-29)NH2 after methionyl-hGH pretreatment
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Pretreatment with 2 IU methionyl-hGH given i.v. abolished the serum GH response to GHRH given 3 h later

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  3. 03HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy men, pyridostigmine restored the GH response to GHRH that methionyl-hGH pretreatment had inhibited.

    In plain wordsIn healthy men, pyridostigmine brought back the growth hormone response to GHRH that a prior growth hormone dose had blocked.

    Peptide
    Sermorelin
    Outcome
    IncreaseRestoration of GH response to GHRH by pyridostigmine after methionyl-hGH
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    this inhibited response to GHRH was restored in subjects given pyridostigmine as well as methionyl-hGH.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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