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Study · Animal study (in vivo) · rat · 1987

4 results

Effect of dermorphin on body temperature in rats.

Broccardo M

Pharmacological research communications1 Oct 1987Cited by 12 (Europe PMC)

PMID2894674 (opens in a new tab)DOI10.1016/0031-6989(87)90101-9 (opens in a new tab)PepBankPUB-02894674
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin produced hypothermia at cold environmental temperatures.

    In plain wordsIn rats, dermorphin lowered body temperature in cold environments.

    Peptide
    Dermorphin
    Outcome
    DecreaseBody temperature in cold environments
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body temperature · Whole body
    Studied dose
    10, 50, 100 ng/rat · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular (icv) injections of dermorphin at dose levels of 10, 50, 100 ng/rat produced hypothermia in animals placed in cold temperatures (-10 degrees C and +4 degrees C) and hyperthermia at ambient (+22 degrees C) and higher temperatures (+34 degrees C).
    1 context sentence
    Summary · context
    The effect of dermorphin on regulation of body temperature was studied in the rat under extreme and thermoneutral environmental temperatures and in different nutritional states.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin produced hyperthermia at ambient and higher environmental temperatures.

    In plain wordsIn rats, dermorphin raised body temperature in ambient and warmer environments.

    Peptide
    Dermorphin
    Outcome
    IncreaseBody temperature in ambient and warmer environments
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body temperature · Whole body
    Studied dose
    10, 50, 100 ng/rat · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular (icv) injections of dermorphin at dose levels of 10, 50, 100 ng/rat produced hypothermia in animals placed in cold temperatures (-10 degrees C and +4 degrees C) and hyperthermia at ambient (+22 degrees C) and higher temperatures (+34 degrees C).
    1 context sentence
    Summary · context
    The effect of dermorphin on regulation of body temperature was studied in the rat under extreme and thermoneutral environmental temperatures and in different nutritional states.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dermorphin produced the same thermoregulatory responses in fed and fasted groups.

    In plain wordsIn rats, dermorphin produced the same temperature responses in fed and fasted groups.

    Peptide
    Dermorphin
    Outcome
    No significant changeThermoregulatory response by nutritional state
    Study

    ratn: not reported in source

    rats
    Comparator
    fed versus fasted rats
    Outcome group
    Body temperature · Whole body
    Studied dose
    10, 50, 100 ng/rat · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The same results were obtained in both experimental groups.
    2 context sentences
    Summary · context
    To determine whether the effect of dermorphin on body temperature was related to the nutritional state of the animal, as observed with other neuropeptides (i.e., bombesin, litorin), the thermoregulatory response was followed in fed and fasted rats.
    Summary · context
    The effect of dermorphin on regulation of body temperature was studied in the rat under extreme and thermoneutral environmental temperatures and in different nutritional states.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, naloxone pretreatment completely prevented dermorphin-induced body temperature changes in all tested conditions.

    In plain wordsIn rats, naloxone pretreatment completely prevented dermorphin-induced temperature changes.

    Peptide
    Dermorphin
    Outcome
    No significant changeNaloxone blockade of temperature changes
    Study

    ratn: not reported in source

    rats
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    10, 50, 100 ng/rat · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    In all cases, dermorphin change in body temperature was mediated via an action on typical opioid receptors since it was completely prevented by pretreatment with naloxone.
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injections of dermorphin at dose levels of 10, 50, 100 ng/rat produced hypothermia in animals placed in cold temperatures (-10 degrees C and +4 degrees C) and hyperthermia at ambient (+22 degrees C) and higher temperatures (+34 degrees C).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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