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Study · Animal study (in vivo) · rat · 1987

2 results

17 beta Estradiol-induced increase in brain dopamine D-2 receptor: antagonism by MIF-1.

Rajakumar G, Chiu P, Chiu S, Johnson RL, Mishra RK

Peptides1 Nov 1987Cited by 8 (Europe PMC)

PMID2894650 (opens in a new tab)DOI10.1016/0196-9781(87)90127-6 (opens in a new tab)PepBankPUB-02894650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, MIF‑1 significantly antagonized the estradiol-induced increase in striatal dopamine D-2 receptor density.

    In plain wordsIn rats, MIF‑1 reduced the estradiol-induced increase in striatal dopamine receptor density.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseStriatal dopamine D-2 receptor density
    Study

    Ratn: not reported in source

    Male rat brain exposed to 17 beta-estradiol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in t…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, MIF‑1 significantly antagonized the estradiol-induced increase in mesolimbic dopamine D-2 receptor density.

    In plain wordsIn rats, MIF‑1 reduced the estradiol-induced increase in mesolimbic dopamine receptor density.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseMesolimbic dopamine D-2 receptor density
    Study

    Ratn: not reported in source

    Male rat brain exposed to 17 beta-estradiol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in t…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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