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Study · Animal study (in vivo) · mouse · 1988

14 results

Inhibition of growth of two human pancreatic adenocarcinomas in vivo by somatostatin analog SMS 201-995.

Upp JR Jr, Olson D, Poston GJ, Alexander RW, Townsend CM Jr, Thompson JC

American journal of surgery1 Jan 1988Cited by 54 (Europe PMC)

PMID2893555 (opens in a new tab)DOI10.1016/s0002-9610(88)80254-x (opens in a new tab)PepBankPUB-02893555
Publisher pagePubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with pancreatic cancer xenografts, body weights did not differ between octreotide and saline groups in any experiment.

    In plain wordsIn mice with pancreatic cancer grafts, body weight did not differ between octreotide and saline groups.

    Peptide
    Octreotide
    Outcome
    No significant changeBody weight
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Mean body weights between groups were not different in any experiment.
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, octreotide begun at SKI transplantation reduced tumor area by the third treatment week versus saline.

    In plain wordsIn mice, octreotide started at SKI cancer transplantation reduced tumor area versus saline by the third week.

    Peptide
    Octreotide
    Outcome
    DecreaseSKI tumor area
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    With treatment beginning on the day of transplantation, the tumor areas of SKI and CAV cancers were reduced by the third and fifth weeks of treatment, respectively.
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, octreotide begun at CAV transplantation reduced tumor area by the fifth treatment week versus saline.

    In plain wordsIn mice, octreotide started at CAV cancer transplantation reduced tumor area versus saline by the fifth week.

    Peptide
    Octreotide
    Outcome
    DecreaseCAV tumor area
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    With treatment beginning on the day of transplantation, the tumor areas of SKI and CAV cancers were reduced by the third and fifth weeks of treatment, respectively.
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with SKI xenografts, octreotide prolonged tumor doubling time (5 days) versus saline.

    In plain wordsIn mice with SKI cancer grafts, octreotide prolonged tumor doubling time (5 days) versus saline.

    Peptide
    Octreotide
    Outcome
    IncreaseSKI tumor doubling time
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Tumor doubling times were prolonged with treatment in both SKI tumors (5 days) and CAV tumors (6 days).
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide prolonged tumor doubling time (6 days) versus saline.

    In plain wordsIn mice with CAV cancer grafts, octreotide prolonged tumor doubling time (6 days) versus saline.

    Peptide
    Octreotide
    Outcome
    IncreaseCAV tumor doubling time
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Tumor doubling times were prolonged with treatment in both SKI tumors (5 days) and CAV tumors (6 days).
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with SKI xenografts, octreotide decreased tumor weight by 52 percent at sacrifice versus saline.

    In plain wordsIn mice with SKI cancer grafts, octreotide reduced tumor weight by 52 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseSKI tumor weight
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the SKI treatment groups, tumor weight (52 percent), RNA content (72 percent), and DNA content (60 percent) were decreased at sacrifice compared with those of the control groups.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with SKI xenografts, octreotide decreased tumor RNA content by 72 percent at sacrifice versus saline.

    In plain wordsIn mice with SKI cancer grafts, octreotide reduced tumor RNA content by 72 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseSKI tumor RNA content
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the SKI treatment groups, tumor weight (52 percent), RNA content (72 percent), and DNA content (60 percent) were decreased at sacrifice compared with those of the control groups.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with SKI xenografts, octreotide decreased tumor DNA content by 60 percent at sacrifice versus saline.

    In plain wordsIn mice with SKI cancer grafts, octreotide reduced tumor DNA content by 60 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseSKI tumor DNA content
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the SKI treatment groups, tumor weight (52 percent), RNA content (72 percent), and DNA content (60 percent) were decreased at sacrifice compared with those of the control groups.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide decreased mean tumor weight by 55 percent versus saline.

    In plain wordsIn mice with CAV cancer grafts, octreotide reduced average tumor weight by 55 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseCAV tumor weight
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the CAV treatment group, the mean tumor weight (55 percent) and protein (48 percent), RNA (67 percent) and DNA contents (60 percent) were decreased compared with the CAV control group.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide decreased tumor protein content by 48 percent versus saline.

    In plain wordsIn mice with CAV cancer grafts, octreotide reduced tumor protein content by 48 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseCAV tumor protein content
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the CAV treatment group, the mean tumor weight (55 percent) and protein (48 percent), RNA (67 percent) and DNA contents (60 percent) were decreased compared with the CAV control group.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide decreased tumor RNA content by 67 percent versus saline.

    In plain wordsIn mice with CAV cancer grafts, octreotide reduced tumor RNA content by 67 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseCAV tumor RNA content
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the CAV treatment group, the mean tumor weight (55 percent) and protein (48 percent), RNA (67 percent) and DNA contents (60 percent) were decreased compared with the CAV control group.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide decreased tumor DNA content by 60 percent versus saline.

    In plain wordsIn mice with CAV cancer grafts, octreotide reduced tumor DNA content by 60 percent versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseCAV tumor DNA content
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitoneal · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In the CAV treatment group, the mean tumor weight (55 percent) and protein (48 percent), RNA (67 percent) and DNA contents (60 percent) were decreased compared with the CAV control group.
    4 context sentences
    Summary · context
    After 7 weeks, the tumors and mouse pancreases were excised, weighed, and analyzed for protein and RNA and DNA content.
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with SKI xenografts, octreotide inhibited tumor growth versus saline when started 21 days after transplantation.

    In plain wordsIn mice with SKI cancer grafts, octreotide started 21 days after transplantation inhibited tumor growth versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseDelayed-treatment SKI tumor growth
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Tumor growth of SKI and CAV cancers was also inhibited when treatment was delayed 21 days after transplantation.
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice with CAV xenografts, octreotide inhibited tumor growth versus saline when started 21 days after transplantation.

    In plain wordsIn mice with CAV cancer grafts, octreotide started 21 days after transplantation inhibited tumor growth versus saline.

    Peptide
    Octreotide
    Outcome
    DecreaseDelayed-treatment CAV tumor growth
    Study

    mousen: not reported in source

    Human pancreatic adenocarcinoma xenografts in nude mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    100 micrograms/kg three times daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Tumor growth of SKI and CAV cancers was also inhibited when treatment was delayed 21 days after transplantation.
    3 context sentences
    Summary · context
    Two human pancreatic cancers grown in nude mice were studied: SKI, which has cholecystokinin receptors, and CAV, which does not.
    Summary · context
    Tumors were implanted in groups of six mice each.
    Summary · context
    Treatment groups received SMS 201-995 (100 micrograms/kg three times daily) by intraperitoneal injections and control animals received saline solution.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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