In early postmenopausal women, bone density response favored salmon calcitonin plus calcium over calcium alone (p less than 0.01).
In plain wordsIn early postmenopausal women, bone density response favored salmon calcitonin plus calcium over calcium alone.
- Peptide
- Calcitonin-salmon
- Outcome
- IncreaseBone mineral density
- Study
n = 79
- Comparator
- Calcium alone
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- 50 IU/day for 5 days per week · intranasal · 12 monthsAs given in this study (human).
Measurements
- Bone mineral density change
- 1.38%
- calcitonin plus calcium, NS
- Bone mineral density change
- −3.16%
- calcium alone
Source sentences
After 12 months of treatment bone mineral density had decreased in the calcium-only group by a mean of 3.16 (SEM 0.6)% (p less than 0.01) but had increased in the calcium plus calcitonin group by 1.38 (0.8)% (NS).
2 context sentences(design, population, supporting numbers)
The difference in response between the two treatment groups was also highly significant (p less than 0.01), as was the difference between values for hydroxyprolinuria/creatininuria (p less than 0.01).
79 women who had been menopausal for less than 36 months and who had not received any form of treatment to prevent bone loss were randomly assigned to a 12-month regimen of calcium 500 mg/day or calcium 500 mg plus intranasal salmon calcitonin 50 IU/day for 5 days per week.