Pituitary-adrenal mediation of dermorphin-induced inhibition of gastric emptying in rats.

Broccardo M

European journal of pharmacology1 Oct 1987Cited by 4 (Europe PMC)

PMID2891542DOI10.1016/0014-2999(87)90666-2PepBankPUB-02891542

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular dermorphin slowed gastric emptying in a dose-related manner.
In plain wordsIn rats, dermorphin slowed stomach emptying as the dose increased.
Peptide
Dermorphin
Outcome
DecreaseGastric emptying
Study
ratn: not reported in source
rats
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
1, 10, 100 ng per rat · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin given i.c.v. (1, 10, 100 ng per rat) slowed emptying in a dose-related manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined.
Report a problemFND-0289154201
02AnimalAnimal study (in vivo)Mechanism
In rats, hypophysectomy or sub-diaphragmatic bivagotomy reduced dermorphin-associated inhibition of gastric emptying.
In plain wordsIn rats, pituitary removal or cutting the vagal nerves reduced dermorphin-associated slowing of stomach emptying.
Peptide
Dermorphin
Outcome
DecreaseDependence of gastric emptying inhibition on pituitary and vagal pathways
Study
ratn: not reported in source
rats
Comparator
intact pathways
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined.
Report a problemFND-0289154202
03AnimalAnimal study (in vivo)Mechanism
In rats, adrenalectomy prevented dermorphin-associated inhibition of gastric emptying.
In plain wordsIn rats, adrenal removal prevented dermorphin-associated slowing of stomach emptying.
Peptide
Dermorphin
Outcome
No significant changeAdrenal dependence of gastric emptying inhibition
Study
ratn: not reported in source
rats
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined.
Report a problemFND-0289154203

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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