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Study · In vitro (cells) · rat · 1987

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The rat posterior pituitary contains a potent prolactin-releasing factor: studies with perifused anterior pituitary cells.

Hyde JF, Murai I, Ben-Jonathan N

Endocrinology1 Oct 1987Cited by 40 (Europe PMC)

PMID2888647 (opens in a new tab)DOI10.1210/endo-121-4-1531 (opens in a new tab)PepBankPUB-02888647
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In perifused rat anterior pituitary cells, oxytocin appeared as a likely prolactin-releasing candidate, and an oxytocin receptor antagonist completely abolished its prolactin-releasing activity.

    In plain wordsIn rat pituitary cells in the lab, oxytocin appeared to trigger prolactin release, and an oxytocin blocker stopped this.

    Peptide
    Oxytocin
    Outcome
    IncreaseProlactin release from perifused anterior pituitary cells
    Study

    ratn: not reported in source

    perifused anterior pituitary cells on Cytodex beads
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of more than 25 neuroactive substances tested in the perifusion system, oxytocin, TRH, and angiotensin II (A II) appeared as likely candidates for PRF.
    2 context sentences
    Summary · context
    These antagonists completely abolished the PRL-releasing activities of their respective peptides
    Summary · context
    Anterior pituitary cells, attached to Cytodex beads, were perifused with medium 199.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    In perifused rat anterior pituitary cells, an oxytocin receptor antagonist failed to reduce the prolactin-releasing activity of posterior pituitary extract, so oxytocin did not account for it.

    In plain wordsIn rat pituitary cells in the lab, blocking oxytocin did not stop the prolactin-releasing activity of pituitary extract.

    Peptide
    Oxytocin
    Outcome
    No significant changeProlactin-releasing activity of posterior pituitary extract with oxytocin antagonist
    Study

    ratn: not reported in source

    perifused anterior pituitary cells on Cytodex beads
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    but failed to reduce the PRF activity of the posterior pituitary.
    2 context sentences
    Summary · context
    3) Although the chemical identity of PRF is yet unknown, the PRF activity in the posterior pituitary is not accounted for by oxytocin, TRH, or A II.
    Summary · context
    Anterior pituitary cells, attached to Cytodex beads, were perifused with medium 199.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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