Skip to content

Study · Animal study (in vivo) · rat · 1987

8 results

Plasma growth hormone (GH) response to intravenous GH-releasing factor (GRF) in adult rats: evidence for transient pituitary desensitization after GRF stimulation.

Arsenijevic Y, Rivest RW, Eshkol A, Sizonenko PC, Aubert ML

Endocrinology1 Oct 1987Cited by 13 (Europe PMC)

PMID2888646 (opens in a new tab)DOI10.1210/endo-121-4-1487 (opens in a new tab)PepBankPUB-02888646
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anaesthetized male rats, intravenous hGRF-(1-29)NH2 raised plasma GH in a dose-dependent way, and 250 ng/kg was the smallest effective dose.

    In plain wordsIn male rats, this peptide raised growth hormone in the blood in a dose-dependent way, starting at 250 ng/kg.

    Peptide
    Sermorelin
    Outcome
    IncreasePlasma GH response in male rats
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    250 ng/kg (smallest effective dose) · intravenousAs given in this study (rat).

    Measurements

    smallest effective dose
    250 ng/kg
    male rats

    Source sentences

    Summary
    Intravenous administration of hGRF-(1-29)NH2 elicited a dose-dependent response of plasma GH, with 250 ng/kg being the smallest effective dose in male rats.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, the GH response to hGRF-(1-29)NH2 was about 60% of that in male rats at each dose tested.

    In plain wordsIn female rats, the growth hormone response to this peptide was lower than in male rats, about 60% of it.

    Peptide
    Sermorelin
    Outcome
    DecreasePlasma GH response in female versus male rats
    Study

    ratn: not reported in source

    Comparator
    Male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    250 to 70,000 ng/kg · intravenousAs given in this study (rat).

    Measurements

    GH response relative to male rats
    ≈ 60%
    female rats

    Source sentences

    Summary
    In female rats, for each dose tested (250 to 70,000 ng/kg), the GH response represented only about 60% that of male rats.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male and female rats, repeated hGRF-(1-29)NH2 stimulations at 45-minute intervals blunted the GH response to the second and third stimulations at every dose.

    In plain wordsIn rats, repeated peptide doses 45 minutes apart gave smaller growth hormone responses to the second and third doses.

    Peptide
    Sermorelin
    Outcome
    DecreasePituitary desensitization after repeated stimulation
    Study

    ratn: not reported in source

    Comparator
    First stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    250 to 70,000 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Repeated iv stimulations with hGRF-(1-29)NH2 at short time intervals (45 min) produced transient desensitization of pituitary responsiveness to GRF: a blunted GH response to the second and third stimulations was observed both in male and in female rats and for each dose tested.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats passively immunized against somatostatin, at least 65% of the inhibition of the GH response after the second GRF stimulation was unrelated to somatostatin action.

    In plain wordsIn rats lacking somatostatin action, most of the smaller second growth hormone response was not caused by somatostatin.

    Peptide
    Sermorelin
    Outcome
    Not applicablePart of blunted GH response unrelated to somatostatin
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    inhibition unrelated to SRIF
    ≥ 65%
    second GRF stimulation, SRIF-immunized rats

    Source sentences

    Summary
    The possibility that these blunted responses could be due to incomplete suppression of hypothalamic SRIF secretion by sodium pentobarbital was excluded by the use of rats that were passively immunized against SRIF; in these rats, it was shown that at least 65% of the inhibition of the GH response af…
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In conscious rats passively immunized against somatostatin, repeated hGRF-(1-29)NH2 stimulations also caused transient desensitization.

    In plain wordsIn awake rats lacking somatostatin action, repeated peptide doses also gave a short-lived drop in growth hormone response.

    Peptide
    Sermorelin
    Outcome
    DecreaseDesensitization in conscious SRIF-immunized rats
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Similar transient desensitization to repeated hGRF-(1-29)NH2 stimulations was also observed in conscious rats that were passively immunized against SRIF.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, blunted GH responses were related to the interval between GRF stimulations; longer intervals gave less or no desensitization.

    In plain wordsIn rats, longer gaps between peptide doses gave less or no loss of growth hormone response.

    Peptide
    Sermorelin
    Outcome
    DecreaseDesensitization versus interval between stimulations
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    This occurrence of blunted responses was shown to be related to the length of the time interval between GRF stimulations, with longer intervals resulting in less or no desensitization.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, each GRF stimulation induced a transient desensitization of pituitary somatotrophs lasting about 1 h.

    In plain wordsIn rats, each peptide dose made the growth hormone-producing cells less responsive for about 1 hour.

    Peptide
    Sermorelin
    Outcome
    Not applicableDuration of pituitary desensitization
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Measurements

    desensitization duration
    ≈ 1 h
    pituitary somatotrophs

    Source sentences

    Summary
    it was shown in this study that in the pituitary level each GRF stimulation also induces a transient desensitization of somatotrophs for about 1 h.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, the refractory period also occurred with the lowest dose of hGRF-(1-29)NH2 that gave a significant GH release.

    In plain wordsIn rats, the loss of response after a first dose also happened with the lowest dose that raised growth hormone.

    Peptide
    Sermorelin
    Outcome
    DecreaseDesensitization at the lowest effective dose
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    it was also observed with the lowest dose of hGRF-(1-29)NH2 that gave a significant release of GH.
    1 context sentence
    Summary · context
    The ability of human (h)GRF-(1-29)NH2 to stimulate GH secretion was studied in cannulated adult rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.