Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism.

Iyer KS, McCann SM

Neuroendocrinology1 Jun 1987Cited by 9 (Europe PMC)

PMID2886936DOI10.1159/000124802PepBankPUB-02886936

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In rat median eminence incubated in vitro, DSIP inhibited somatostatin release in a dose-dependent manner.
In plain wordsIn rat brain tissue in a dish, DSIP reduced the release of somatostatin as the dose rose.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseSomatostatin release from median eminence
Study
ratn: not reported in source
Rat median eminence, in vitro incubation
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
DSIP inhibited SRIF release in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of DSIP on somatostatin (SRIF) release from the median eminence of the hypothalamus was evaluated in male and female rats in an in vitro incubation system.
Report a problemFND-0288693601
02LabEx vivo tissueEfficacy outcome
In rat median eminence in vitro, DSIP inhibited somatostatin release in both sexes, with less sensitivity in females than in males and maximum effect at 10(-8) M.
In plain wordsIn rat brain tissue in a dish, DSIP reduced somatostatin release in both sexes, but less in females.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseSex difference in DSIP inhibition of somatostatin release
Study
ratn: not reported in source
Rat median eminence, in vitro incubation
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The median eminences from females were less sensitive to the inhibitory action of DSIP than those of males; however, in both sexes the maximum effect was observed at a concentration of 10(-8) M DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of DSIP on somatostatin (SRIF) release from the median eminence of the hypothalamus was evaluated in male and female rats in an in vitro incubation system.
Report a problemFND-0288693602
03LabEx vivo tissueMechanism
In rat median eminence in vitro, pimozide at 10(-6) M blocked the inhibition of somatostatin release by DSIP.
In plain wordsIn rat brain tissue in a dish, a dopamine blocker stopped the DSIP-driven drop in somatostatin release.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicablePimozide blockade of DSIP effect on somatostatin release
Study
ratn: not reported in source
Rat median eminence, in vitro incubation
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
This effect was blocked by addition of pimozide at a concentration of 10(-6) M.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of DSIP on somatostatin (SRIF) release from the median eminence of the hypothalamus was evaluated in male and female rats in an in vitro incubation system.
Report a problemFND-0288693603

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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