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Study · Animal study (in vivo) · mouse · 1985

3 results

Dose- and strain-dependent effects of dermorphin and [D-Ala2-D-Leu5]enkephalin on passive avoidance behavior in mice.

Castellano C, Pavone F

Behavioral neuroscience1 Dec 1985Cited by 13 (Europe PMC)

PMID2886135 (opens in a new tab)DOI10.1037//0735-7044.99.6.1120 (opens in a new tab)PepBankPUB-02886135
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In DBA and C57 mice, dermorphin at the low dose impaired passive avoidance retention.

    In plain wordsIn mice of both strains, low-dose dermorphin impaired retention in the passive avoidance test.

    Peptide
    Dermorphin
    Outcome
    DecreasePassive avoidance retention
    Study

    micen: not reported in source

    DBA/2 and C57BL/6 mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    5 ng · intracerebroventricularAs given in this study (mice).

    Source sentences

    Summary
    In fact, the peptides impaired, at a low dose (5 ng), the retention performances of both strains;
    1 context sentence
    Summary · context
    Dermorphin and [D-Ala2-D-Leu5]enkephalin, administered intracerebroventricularly (icv) immediately after training in a passive avoidance test, exerted dose- and strain-dependent effects in DBA/2 (DBA) and C57BL/6 (C57) mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In DBA mice, the higher dermorphin dose impaired passive avoidance retention.

    In plain wordsIn DBA mice, the higher dermorphin dose impaired retention in the passive avoidance test.

    Peptide
    Dermorphin
    Outcome
    DecreasePassive avoidance retention in DBA mice
    Study

    micen: not reported in source

    DBA/2 mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    50 ng · intracerebroventricularAs given in this study (mice).

    Source sentences

    Summary
    a higher dose (50 ng) impaired retention in DBA but improved it in C57 mice.
    1 context sentence
    Summary · context
    Dermorphin and [D-Ala2-D-Leu5]enkephalin, administered intracerebroventricularly (icv) immediately after training in a passive avoidance test, exerted dose- and strain-dependent effects in DBA/2 (DBA) and C57BL/6 (C57) mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In C57 mice, the higher dermorphin dose improved passive avoidance retention.

    In plain wordsIn C57 mice, the higher dermorphin dose improved retention in the passive avoidance test.

    Peptide
    Dermorphin
    Outcome
    IncreasePassive avoidance retention in C57 mice
    Study

    micen: not reported in source

    C57BL/6 mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    50 ng · intracerebroventricularAs given in this study (mice).

    Source sentences

    Summary
    a higher dose (50 ng) impaired retention in DBA but improved it in C57 mice.
    1 context sentence
    Summary · context
    Dermorphin and [D-Ala2-D-Leu5]enkephalin, administered intracerebroventricularly (icv) immediately after training in a passive avoidance test, exerted dose- and strain-dependent effects in DBA/2 (DBA) and C57BL/6 (C57) mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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