Effect of somatostatin analogue (SMS 201-995, Sandostatin) on pancreatic secretion in humans.

Creutzfeldt W, Lembcke B, Fölsch UR, Schleser S, Koop I

The American journal of medicine1 May 1987Cited by 47 (Europe PMC)

PMID2884879DOI10.1016/0002-9343(87)90426-8PepBankPUB-02884879

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanNon-randomized trialMechanism
In healthy subjects, octreotide completely inhibited pancreatic enzyme secretion after a Lundh meal versus placebo.
In plain wordsIn healthy people, octreotide blocked pancreatic enzyme secretion after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced pancreatic enzyme secretion
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
Pancreatic enzyme secretion, gall bladder contraction, and cholecystokinin response after a Lundh meal were completely inhibited by SMS, while pancreatic enzyme secretion elicited by intravenous injection of secretin and pancreozymin was suppressed by 80 percent.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487901
02HumanNon-randomized trialMechanism
In healthy subjects, octreotide completely inhibited gallbladder contraction after a Lundh meal versus placebo.
In plain wordsIn healthy people, octreotide blocked gallbladder contraction after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced gallbladder contraction
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
Pancreatic enzyme secretion, gall bladder contraction, and cholecystokinin response after a Lundh meal were completely inhibited by SMS, while pancreatic enzyme secretion elicited by intravenous injection of secretin and pancreozymin was suppressed by 80 percent.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487902
03HumanNon-randomized trialMechanism
In healthy subjects, octreotide completely inhibited the CCK response after a Lundh meal versus placebo.
In plain wordsIn healthy people, octreotide blocked the CCK response after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced CCK response
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
Pancreatic enzyme secretion, gall bladder contraction, and cholecystokinin response after a Lundh meal were completely inhibited by SMS, while pancreatic enzyme secretion elicited by intravenous injection of secretin and pancreozymin was suppressed by 80 percent.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487903
04HumanNon-randomized trialMechanism
In healthy subjects, octreotide suppressed pancreatic enzyme secretion elicited by secretin and pancreozymin injection by 80 percent.
In plain wordsIn healthy people, octreotide reduced pancreatic enzyme secretion after secretin and pancreozymin by 80 percent versus placebo.
Peptide
Octreotide
Outcome
DecreaseSecretin and pancreozymin-stimulated enzymes
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Measurements
Suppression of secretin- and pancreozymin-stimulated pancreatic enzyme secretion
80 percent
SMS 201-995 in healthy subjects
Source sentences
Summary
Pancreatic enzyme secretion, gall bladder contraction, and cholecystokinin response after a Lundh meal were completely inhibited by SMS, while pancreatic enzyme secretion elicited by intravenous injection of secretin and pancreozymin was suppressed by 80 percent.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487904
05HumanNon-randomized trialMechanism
In healthy subjects, octreotide fully inhibited endogenous CCK release on the sixth treatment day.
In plain wordsIn healthy people, octreotide still fully blocked natural CCK release versus placebo on the sixth treatment day.
Peptide
Octreotide
Outcome
DecreaseEndogenous CCK release inhibition on sixth day
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneous · 6 daysAs given in this study (human).
Source sentences
Summary
The inhibitory effect of SMS on endogenous cholecystokinin release was fully operative on the sixth day of injection treatment
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487905
06HumanNon-randomized trialMechanism
In healthy subjects, the inhibitory effect of octreotide on the response to exogenous CCK injection significantly decreased after 7 days of administration, which the authors read as end-organ desensitization.
In plain wordsIn healthy people, octreotide's blocking of the response to injected CCK became significantly weaker after seven days.
Peptide
Octreotide
Outcome
DecreaseInhibition of response to exogenous CCK
Study
n: not reported in source
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneous · 7 daysAs given in this study (human).
Source sentences
Summary
whereas the inhibitory effect on exogenous cholecystokinin injection significantly decreased after SMS administration for seven days, indicating desensitization of the end organ by somatostatin.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487906
07HumanNon-randomized trialMechanism
In healthy subjects, octreotide abolished pancreatic polypeptide release after a solid test meal versus placebo.
In plain wordsIn healthy people, octreotide blocked pancreatic polypeptide release after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced pancreatic polypeptide release
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms · subcutaneousAs given in this study (human).
Source sentences
Summary
The release of pancreatic polypeptide by a solid test meal is abolished by administration of 25 micrograms of SMS
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487907
08HumanNon-randomized trialMechanism
In healthy subjects, octreotide nearly completely suppressed gastric inhibitory polypeptide release after a test meal versus placebo.
In plain wordsIn healthy people, octreotide nearly blocked gastric inhibitory polypeptide release after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced gastric inhibitory polypeptide release
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
the release of gastric inhibitory polypeptide is nearly completely suppressed
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487908
09HumanNon-randomized trialMechanism
In healthy subjects, octreotide significantly lowered the insulin response after a test meal versus placebo.
In plain wordsIn healthy people, octreotide lowered the insulin response after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced insulin response
Study
n: not reported in source
Comparator
Placebo
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
the response of insulin and C-peptide are significantly lowered
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487909
10HumanNon-randomized trialMechanism
In healthy subjects, octreotide significantly lowered the C-peptide response after a test meal versus placebo.
In plain wordsIn healthy people, octreotide lowered the C-peptide response after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced C-peptide response
Study
n: not reported in source
Comparator
Placebo
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
the response of insulin and C-peptide are significantly lowered
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487910
11HumanNon-randomized trialMechanism
In healthy subjects, octreotide only slightly reduced the gastrin response after a test meal versus placebo.
In plain wordsIn healthy people, octreotide slightly reduced the gastrin response after food versus placebo.
Peptide
Octreotide
Outcome
DecreaseMeal-induced gastrin response
Study
n: not reported in source
Comparator
Placebo
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
25 micrograms twice daily · subcutaneousAs given in this study (human).
Source sentences
Summary
and the gastrin response is only slightly reduced.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.
Summary · context
SMS 201-995 was administered subcutaneously at a dose of 25 micrograms twice daily, and all tests were performed 30 minutes after the morning injection.
Report a problemFND-0288487911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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