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Study · Animal study (in vivo) · mouse · 1987

4 results

C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol.

Szabó G, Kovács GL, Székeli S, Baláspiri L, Telegdy G

Acta physiologica Hungarica1 Jan 1987Cited by 9 (Europe PMC)

PMID2884803 (opens in a new tab)PepBankPUB-02884803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ethanol-naive mice, PLG treatment did not affect body temperature.

    In plain wordsIn mice without ethanol exposure, PLG did not affect body temperature.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeBody temperature in ethanol-naive mice
    Study

    mousen: not reported in source

    CFLP mice
    Outcome group
    Body temperature · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peptide treatment did not affect body temperature in ethanol-naive animals.
    1 context sentence
    Summary · context
    The actions of different doses of the C-terminal tripeptide (prolyl-leucyl-glycinamide, PLG) and of a synthetic dipeptide derivative (Z-prolyl-D-leucine, Z-Pro-D-Leu) on the development of tolerance to the hypothermic effect of ethanol in CFLP mice were therefore investigated.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, PLG did not affect hypothermia after a single ethanol injection.

    In plain wordsIn mice, PLG did not change reduced body temperature after a single ethanol injection.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeAcute ethanol-induced hypothermia
    Study

    mousen: not reported in source

    CFLP mice
    Outcome group
    Body temperature · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute effects (hypothermia, sleeping time) of a single ethanol injection were also unaffected by these peptides.
    1 context sentence
    Summary · context
    The actions of different doses of the C-terminal tripeptide (prolyl-leucyl-glycinamide, PLG) and of a synthetic dipeptide derivative (Z-prolyl-D-leucine, Z-Pro-D-Leu) on the development of tolerance to the hypothermic effect of ethanol in CFLP mice were therefore investigated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, PLG did not affect sleeping time after a single ethanol injection.

    In plain wordsIn mice, PLG did not change sleeping time after a single ethanol injection.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeSleeping time after acute ethanol
    Study

    mousen: not reported in source

    CFLP mice
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute effects (hypothermia, sleeping time) of a single ethanol injection were also unaffected by these peptides.
    1 context sentence
    Summary · context
    The actions of different doses of the C-terminal tripeptide (prolyl-leucyl-glycinamide, PLG) and of a synthetic dipeptide derivative (Z-prolyl-D-leucine, Z-Pro-D-Leu) on the development of tolerance to the hypothermic effect of ethanol in CFLP mice were therefore investigated.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, PLG inhibited development of tolerance to the hypothermic effect of ethanol.

    In plain wordsIn mice, PLG reduced development of tolerance to ethanol-induced decreases in body temperature.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseTolerance to ethanol-induced hypothermia
    Study

    mousen: not reported in source

    CFLP mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, both PLG and Z-Pro-D-Leu inhibited the development of tolerance to the hypothermic effect of ethanol.
    1 context sentence
    Summary · context
    The actions of different doses of the C-terminal tripeptide (prolyl-leucyl-glycinamide, PLG) and of a synthetic dipeptide derivative (Z-prolyl-D-leucine, Z-Pro-D-Leu) on the development of tolerance to the hypothermic effect of ethanol in CFLP mice were therefore investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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