Skip to content

Study · Animal study (in vivo) · cepaea nemoralis · 1987

4 results

MIF-1 and Tyr-MIF-1 antagonize morphine and opioid but not non-opioid stress-induced analgesia in the snail, Cepaea nemoralis.

Kavaliers M

Peptides1 Jan 1987Cited by 19 (Europe PMC)

PMID2883631 (opens in a new tab)DOI10.1016/0196-9781(87)90155-0 (opens in a new tab)PepBankPUB-02883631
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In snails, MIF‑1 blocked morphine-induced opioid analgesia.

    In plain wordsIn snails, MIF‑1 blocked morphine-induced pain relief compared with morphine without MIF‑1.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseMorphine-induced analgesia
    Study

    Cepaea nemoralisn: not reported in source

    thermal avoidance in terrestrial snails
    Comparator
    morphine without MIF-1
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All three substances blocked the morphine- and warm stress-induced opioid analgesia, while having no effects on non-opioid cold stress-induced analgesia.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and naloxone on morphine and warm and cold stress-induced increases in the latency of the thermal (40 degrees C hot plate) avoidance behaviors of the terrestrial snail, Cepaea nemoralis, were examined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In snails, MIF‑1 blocked warm stress-induced opioid analgesia.

    In plain wordsIn snails, MIF‑1 blocked warm stress-induced pain relief compared with warm stress without MIF‑1.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseWarm stress-induced analgesia
    Study

    Cepaea nemoralisn: not reported in source

    thermal avoidance in terrestrial snails
    Comparator
    warm stress without MIF-1
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All three substances blocked the morphine- and warm stress-induced opioid analgesia, while having no effects on non-opioid cold stress-induced analgesia.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and naloxone on morphine and warm and cold stress-induced increases in the latency of the thermal (40 degrees C hot plate) avoidance behaviors of the terrestrial snail, Cepaea nemoralis, were examined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In snails, MIF‑1 did not affect non-opioid cold stress-induced analgesia.

    In plain wordsIn snails, MIF‑1 did not change cold stress-induced pain relief compared with cold stress without MIF‑1.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeCold stress-induced analgesia
    Study

    Cepaea nemoralisn: not reported in source

    thermal avoidance in terrestrial snails
    Comparator
    cold stress without MIF-1
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All three substances blocked the morphine- and warm stress-induced opioid analgesia, while having no effects on non-opioid cold stress-induced analgesia.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and naloxone on morphine and warm and cold stress-induced increases in the latency of the thermal (40 degrees C hot plate) avoidance behaviors of the terrestrial snail, Cepaea nemoralis, were examined.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In snails, MIF‑1 inhibited analgesia less than Tyr-MIF‑1.

    In plain wordsIn snails, MIF‑1 inhibited pain relief less than Tyr-MIF‑1.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseInhibition of analgesia versus Tyr-MIF-1
    Study

    Cepaea nemoralisn: not reported in source

    thermal avoidance in terrestrial snails
    Comparator
    Tyr-MIF-1
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tyr-MIF-1 had a significantly greater inhibitory effect than MIF-1.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and naloxone on morphine and warm and cold stress-induced increases in the latency of the thermal (40 degrees C hot plate) avoidance behaviors of the terrestrial snail, Cepaea nemoralis, were examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.