In healthy volunteers, octreotide reduced gastric half-emptying time from 37.2 +/- 3.3 to 23.3 +/- 3.4 min versus control (p less than 0.01).
In plain wordsIn healthy volunteers, octreotide accelerated stomach emptying compared with the control study.
- Peptide
- Octreotide
- Outcome
- DecreaseGastric half-emptying time
- Study
n = 8
- Comparator
- Control study
- Outcome group
- Gastrointestinal motility · Gastrointestinal
- Studied dose
- 50 micrograms once · subcutaneousAs given in this study (human).
Measurements
- Time to 50% isotope disappearance
- 37.2 min
- control study; +/- 3.3 (dispersion type not stated)
- Time to 50% isotope disappearance
- 23.3 min
- after SMS injection; +/- 3.4 (dispersion type not stated)
- p value
- < 0.01 not applicable
- control versus after SMS injection
Source sentences
Gastric emptying was accelerated, with a significant reduction of the time taken to 50% isotope disappearance (37.2 +/- 3.3 min during control study vs 23.3 +/- 3.4 min after SMS injection; p less than 0.01).
1 context sentence(design, population, supporting numbers)
The effect on gut motility of a single subcutaneous injection of 50 micrograms of the long-acting somatostatin analogue, SMS 201-995, was investigated in 8 normal volunteers who took a drink containing 99mTc and lactulose with a mixed meal.