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Study · Animal study (in vivo) · mouse · 1986

3 results

Inhibitory influences of MIF-1 (PLG) and Tyr-MIF-1 (YPLG) on aggression and defeat-induced analgesia in mice.

Kavaliers M, Hirst M

Peptides1 Nov 1986Cited by 25 (Europe PMC)

PMID2882493 (opens in a new tab)DOI10.1016/0196-9781(86)90129-4 (opens in a new tab)PepBankPUB-02882493
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, MIF‑1 reduced the number of bites required to obtain defeat in subordinate mice.

    In plain wordsIn mice, MIF‑1 reduced the number of bites required to defeat subordinate mice.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseBites required for defeat
    Study

    Mousen: not reported in source

    Male mice during aggressive encounters
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All three substances reduced the number of bites required to obtain defeat in subordinate mice during aggressive encounters, as well as blocking subsequent defeat-induced analgesia.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and the exogenous opiate antagonist, naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, MIF‑1 blocked subsequent defeat-induced analgesia.

    In plain wordsIn mice, MIF‑1 blocked the pain-reducing effect that followed defeat.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDefeat-induced analgesia
    Study

    Mousen: not reported in source

    Male mice during aggressive encounters
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All three substances reduced the number of bites required to obtain defeat in subordinate mice during aggressive encounters, as well as blocking subsequent defeat-induced analgesia.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and the exogenous opiate antagonist, naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, MIF‑1 had significantly weaker inhibitory effects than Tyr-MIF‑1.

    In plain wordsIn mice, MIF‑1 had weaker inhibitory effects than Tyr-MIF‑1.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseInhibitory effects versus Tyr-MIF-1
    Study

    Mousen: not reported in source

    Male mice during aggressive encounters
    Comparator
    Tyr-MIF-1
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tyr-MIF-1 had significantly greater inhibitory effects than MIF.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and the exogenous opiate antagonist, naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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