Skip to content

Study · Non-randomized trial · n = 86 · 1986

7 results

Testing with growth hormone-releasing factor (GRF(1-29)NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency.

Ranke MB, Gruhler M, Rosskamp R, Brügmann G, Attanasio A, Blum WF, Bierich JR

European journal of pediatrics1 Dec 1986Cited by 11 (Europe PMC)

PMID2880720 (opens in a new tab)DOI10.1007/bf02429048 (opens in a new tab)PepBankPUB-02880720
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children without GHD, the maximal GH response to GRF(1-29)NH2 was not correlated with age, sex or pubertal development.

    In plain wordsIn children without growth hormone deficiency, the growth hormone response to GRF did not depend on age, sex or puberty stage.

    Peptide
    Sermorelin
    Outcome
    No significant changeMaximal GH response by age, sex and puberty in children without GHD
    Study

    n = 86

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    In cases without GHD no correlation to age, sex and pubertal development was observed.
    1 context sentence
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.
  2. 02HumanNon-randomized trialOther

    In 3 of 86 children without GHD, maximal GH after GRF(1-29)NH2 fell short of 10 ng/ml, the level taken as normal.

    In plain wordsIn 3 of 86 children without growth hormone deficiency, the test response was below the normal cut-off of 10 ng/ml.

    Peptide
    Sermorelin
    Outcome
    Not applicableNon-GHD children with maximal GH below 10 ng/ml
    Study

    n = 86

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Measurements

    Children without GHD with max GH below 10 ng/ml
    3 children
    86 children without GHD

    Source sentences

    Summary
    A maximal GH level of above 10 ng/ml was found to be normal.
    2 context sentences
    Summary · context
    In 3 out of 86 children without GHD (one with Turner syndrome; two with simple obesity) max GH fell short of 10 ng/ml
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.
  3. 03HumanNon-randomized trialOther

    In 11 of 45 children with GHD, maximal GH after GRF(1-29)NH2 exceeded the 10 ng/ml normal margin.

    In plain wordsIn 11 of 45 children with growth hormone deficiency, the test response was above the normal cut-off of 10 ng/ml.

    Peptide
    Sermorelin
    Outcome
    Not applicableGHD children with maximal GH above 10 ng/ml
    Study

    n = 45

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Measurements

    GHD children with max GH above 10 ng/ml
    11 children
    45 children with GHD

    Source sentences

    Summary
    11 of 45 cases with GHD exceeded this margin.
    1 context sentence
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.
  4. 04HumanNon-randomized trialEfficacy outcome

    In 11 young adult volunteers, GRF(1-29)NH2 and GRF(1-40) gave identical GH responses.

    In plain wordsIn 11 young adults, the shorter GRF peptide gave the same growth hormone response as the longer one.

    Peptide
    Sermorelin
    Outcome
    No significant changeGH response, GRF(1-40) versus GRF(1-29)NH2
    Study

    n = 11

    Comparator
    GRF(1-40)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    Comparison between GRF(1-40) and GRF(1-29)NH2 in 11 young adult volunteers gave identical results.
  5. 05HumanNon-randomized trialOther

    In children with GHD, the maximal GH response to GRF was inversely correlated with age.

    In plain wordsIn children with growth hormone deficiency, older children had a lower growth hormone response to GRF.

    Peptide
    Sermorelin
    Outcome
    Not applicableMaximal GH response and age in GHD
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    In GHD, max GH was inversely correlated with age.
    1 context sentence
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.
  6. 06HumanNon-randomized trialEfficacy outcome

    In children with GHD, the maximal GH response did not differ between groups with or without perinatal pathology.

    In plain wordsIn children with growth hormone deficiency, the response to GRF was the same with or without birth-related problems.

    Peptide
    Sermorelin
    Outcome
    No significant changeMaximal GH response and perinatal pathology in GHD
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    There was no difference in max GH between groups with or without perinatal pathology as a presumed cause of GHD.
    1 context sentence
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.
  7. 07HumanNon-randomized trialOther

    In GHD, GH levels to GRF correlated positively with maximal sleep GH but not with the responses to insulin or arginine.

    In plain wordsIn growth hormone deficiency, the GRF response was linked to growth hormone during sleep, but not to the responses in insulin or arginine tests.

    Peptide
    Sermorelin
    Outcome
    MixedGH response to GRF and other GH stimulation tests in GHD
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg BW · intravenous · single doseAs given in this study (human).

    Source sentences

    Summary
    GH levels to GRF were positively correlated with maximal GH level during sleep in GHD, but not correlated with responses seen to insulin or arginine.
    1 context sentence
    Summary · context
    One hundred and thirty-one children and adolescents (45 with idiopathic GHD) were tested with GRF (1-29)NH2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.